1CT2: OMTKY3 P1 variant OMTKY3-THR18I

Crystal structure of the OMTKY3 P1 variant OMTKY3-THR18I in complex with sgpb. Determined by X-ray diffraction at 1.65 Å resolution. Released 12 Jan 2000.

Method: X-ray diffraction
Resolution: 1.65 Å
Organisms: Streptomyces griseus, Meleagris gallopavo
Chains: 2
Atoms: 1,874
Mol. weight: 24.24 kDa
Released: 12 Jan 2000

Explore 1CT2 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1CT2 contains 4 α-helices and 24 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain E: 2 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	18	1	1
β-strand	30-32	3	2
β-strand	41-43	3	2
β-strand	46-48B	5	2
β-strand	49-54	6	2
α-helix	56-59	4
β-strand	65-67	3	2
β-strand	84-93	9	2
β-strand	100	1	3
β-strand	103-108	6	2
β-strand	118-119	2	1
β-strand	122-123	2	1
β-strand	126-127	2	3
β-strand	135-140	6	3
β-strand	156-170	15	3
β-strand	176-183	8	3
β-strand	198-201	4	3
β-strand	208-219	12	3
β-strand	223-230	8	3
α-helix	231-237	8
β-strand	240-241	2	2

Chain I: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	16-17	2	3
β-strand	20	1	2
β-strand	23-25	3	4
α-helix	29	1
β-strand	30-31	2	4
α-helix	34-43	10
β-strand	50-53	4	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Proteinase B	E	protein	185	Streptomyces griseus	P00777 (AlphaFold model)
Ovomucoid inhibitor	I	protein	51	Meleagris gallopavo	P68390 (AlphaFold model)

Sequence of entity 1 (E), FASTA

>1CT2_1 PROTEINASE B (chains E)
ISGGDAIYSSTGRCSLGFNVRSGSTYYFLTAGHCTDGATTWWANSARTTVLGTTSGSSFP
NNDYGIVRYTNTTIPKDGTVGGQDITSAANATVGMAVTRRGSTTGTHSGSVTALNATVNY
GGGDVVYGMIRTNVCAEPGDSGGPLYSGTRAIGLTSGGSGNCSSGGTTFFQPVTEALVAY
GVSVY

Sequence of entity 2 (I), FASTA

>1CT2_2 OVOMUCOID INHIBITOR (chains I)
VDCSEYPKPACTTEYRPLCGSDNKTYGNKCNFCNAVVESNGTLTLSHFGKC

Primary citation

Deleterious effects of beta-branched residues in the S1 specificity pocket of Streptomyces griseus proteinase B (SGPB): crystal structures of the turkey ovomucoid third domain variants Ile18I, Val18I, Thr18I, and Ser18I in complex with SGPB. Bateman, K.S., Anderson, S., Lu, W. et al. Protein Sci (2000) 9:83-94. PubMed

Other PDB entries of the same protein (UniProt P00777 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2QA9 1.18 Å, Crystal structure of the second tetrahedral intermediates of SGPB at pH 4.2
2QAA 1.23 Å, Crystal structure of the second tetrahedral intermediates of SGPB at pH 7.3
1SGP 1.4 Å, Ala 18 variant of turkey ovomucoid inhibitor third domain complexed with streptomyces…
1CT4 1.6 Å, Crystal structure of the OMTKY3 P1 variant OMTKY3-VAL18I in complex with sgpb
2NU2 1.65 Å, Accommodation of positively-charged residues in a hydrophobic specificity pocket:…
1DS2 1.7 Å, Crystal structure of SGPB:OMTKY3-coo-LEU18I
2GKV 1.7 Å, Crystal structure of the SGPB:P14'-Ala32 OMTKY3-del(1-5) complex
2NU4 1.75 Å, Accommodation of positively-charged residues in a hydrophobic specificity pocket:…
2SGF 1.75 Å, Phe 18 variant of turkey ovomucoid inhibitor third domain complexed with streptomyces…
1CT0 1.8 Å, Crystal structure of the OMTKY3 P1 variant OMTKY3-SER18I in complex with sgpb
1SGD 1.8 Å, Asp 18 variant of turkey ovomucoid inhibitor third domain complexed with streptomyces…
1SGE 1.8 Å, Glu 18 variant of turkey ovomucoid inhibitor third domain complexed with streptomyces…

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