1DOM: MCP-1

Solution structure of the monocyte chemoattractant protein-1 dimer using heteronuclear, NMR, minimized average structure. Determined by solution NMR. Released 14 Oct 1996.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 1,214
Mol. weight: 17.4 kDa
Released: 14 Oct 1996

Explore 1DOM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1DOM contains 2 α-helices and 12 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 1 helix, 6 β-strands

Element	Residues	Length	Sheet
β-strand	9-11	3	1
β-strand	27-28	2	2
β-strand	31	1	3
β-strand	40	1	3
β-strand	41-44	4	2
β-strand	50-53	4	2
α-helix	60-68	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MCP-1	A, B	protein	76	Homo sapiens	P13500 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>1DOM_1 MCP-1 (chains A, B)
QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWV
QDSMDHLDKQTQTPKT

Primary citation

Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer. Handel, T.M., Domaille, P.J. Biochemistry (1996) 35:6569-6584. DOI 10.1021/bi9602270 · PubMed

Other PDB entries of the same protein (UniProt P13500 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7SO0 1.74 Å, Crystal Structure of the Engineered Tick Evasin EVA-P974(F31A) Complexed to Human…
1DOK 1.85 Å, Monocyte chemoattractant protein 1, P-form
3IFD 1.9 Å, Human synthetic monocyte chemoattractant protein 1 (MCP-1)
4R8I 2.05 Å, High Resolution Structure of a Mirror-Image RNA Oligonucleotide Aptamer in Complex with…
1DOL 2.4 Å, Monocyte chemoattractant protein 1, I-form
2NZ1 2.5 Å, Viral Chemokine Binding Protein M3 From Murine Gammaherpesvirus68 In Complex With The…
2BDN 2.53 Å, Crystal structure of human MCP-1 bound to a blocking antibody, 11K2
4ZK9 2.6 Å, The chemokine binding protein of orf virus complexed with CCL2
1ML0 2.8 Å, Viral chemokine binding protein M3 from murine GAMMAHERPESVIRUS68 in complex with the…
4DN4 2.8 Å, Crystal structure of the complex between cnto888 fab and mcp-1 mutant p8a
7XA3 2.9 Å, Cryo-EM structure of the CCL2 bound CCR2-Gi complex
8FJ0 2.91 Å, Crystal Structure of the Tick Evasin EVA-AAM1001(Y44A) Complexed to Human Chemokine CCL2

Browse structure collections

About this viewer

MolViewer shows 1DOM directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.