1EH6: Human O6-alkylguanine-DNA alkyltransferase

Name: PDB 1EH6: Human O6-alkylguanine-DNA alkyltransferase
Published: 2000-04-12
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transferase

Human O6-alkylguanine-DNA alkyltransferase. Determined by X-ray diffraction at 2.0 Å resolution. Released 12 Apr 2000.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,426
Mol. weight: 21.74 kDa
Ligands: ZN
Released: 12 Apr 2000

Explore 1EH6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1EH6 contains 9 α-helices and 9 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	8-12	5	1
β-strand	19-24	6	1
β-strand	27-33	7	1
β-strand	50	1	1
α-helix	57-71	15
α-helix	73-78	6
α-helix	80-83	4
β-strand	84	1	1
α-helix	87-90	4
α-helix	94-105	12
β-strand	112-113	2	2
α-helix	114-120	7
α-helix	127-133	7
β-strand	140	1	3
β-strand	143	1	3
α-helix	145-147	3
β-strand	148-149	2	2
α-helix	162-171	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
O6-alkylguanine-DNA alkyltransferase	A	protein	207	Homo sapiens	P16455 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1EH6_1 O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE (chains A)
MDKDCEMKRTTLDSPLGKLELSGCEQGLHEIKLLGKGTSAADAVEVPAPAAVLGGPEPLM
QCTAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAAL
AGNPKAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGHRLGKPG
LGGSSGLAGAWLKGAGATSGSPPAGRN

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Primary citation

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding. Daniels, D.S., Mol, C.D., Arvai, A.S. et al. EMBO J (2000) 19:1719-1730. DOI 10.1093/emboj/19.7.1719 · PubMed

Other PDB entries of the same protein (UniProt P16455 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1QNT 1.9 Å, X-ray structure of human O6alkylguanine-DNA alkyltransferase
1EH7 2.0 Å, Methylated human O6-alkylguanine-DNA alkyltransferase
9QF2 2.42 Å, Cryo-EM structure of the fully Coronin-1B-decorated actin filament in the ADP state.
1EH8 2.5 Å, Benzylated human O6-alkylguanine-DNA alkyltransferase
28OP 2.7 Å, Structure of the human inner kinetochore CCAN and CENP-C bound to DNA
9QEY 2.74 Å, Cryo-EM structure of the actin filament bound by a single Coronin-1B molecule.
9QFB 2.74 Å, Cryo-EM structure of the fully Coronin-1B-decorated actin filament in the ADP state.
9QFQ 2.76 Å, Cryo-EM structure of the cofilactin barbed end bound by AIP1
1YFH 3.01 Å, wt Human O6-Alkylguanine-DNA Alkyltransferase Bound To DNA Containing an Alkylated…
9DI0 3.1 Å, Cryo-EM structure of Kif18A bound to a microtubule
9QFE 3.12 Å, Cryo-EM structure of the actin filament hetero-decorated by Coronin-1 and Cofilin-1 on…
9QFW 3.16 Å, Cryo-EM structure of the cofilactin barbed end bound by two AIP1 molecules

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