1F8H: Second EPS15 homology domain of human EPS15

Structure of the second EPS15 homology domain of human EPS15 in complex with ptgssstnpfr. Determined by solution NMR. Released 1 Nov 2000.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 794
Mol. weight: 11.75 kDa
Ligands: CA
Released: 1 Nov 2000

Explore 1F8H in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1F8H contains 5 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	11-21	11
β-strand	32	1	1
α-helix	33-41	9
α-helix	47-57	11
β-strand	64	1	1
α-helix	69-82	14
α-helix	97-99	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Epidermal growth factor receptor substrate 15	A	protein	95	Homo sapiens	P42566 (AlphaFold model)
Ptgssstnpfr	B	protein	11

Sequence of entity 1 (A), FASTA

>1F8H_1 EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE 15 (chains A)
PWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGML
DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKR

Sequence of entity 2 (B), FASTA

>1F8H_2 PTGSSSTNPFR (chains B)
PTGSSSTNPFR

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	1

Primary citation

Molecular mechanism of NPF recognition by EH domains. de Beer, T., Hoofnagle, A.N., Enmon, J.L. et al. Nat Struct Biol (2000) 7:1018-1022. DOI 10.1038/80924 · PubMed

Other PDB entries of the same protein (UniProt P42566 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4RHG 1.58 Å, Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with Eps15 pTyr849…
4RH9 1.6 Å, Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849…
4RH5 1.6 Å, Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 peptide
4S0G 1.72 Å, Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 P850V peptide
2IV9 1.9 Å, B2-appendage from AP2 in complex with Eps15 peptide
5JP2 2.4 Å, Fcho1 Mu homology domain (Danio Rerio) with bound Eps15 peptide
5AWU 2.7 Å, Crystal structure of the SGIP1 mu homology domain in complex with an Eps15 fragment…
5AWT 2.7 Å, Crystal structure of the SGIP1 mu homology domain in complex with an Eps15 fragment…
1C07 Structure of the third EPS15 homology domain of human EPS15
1EH2 Structure of the second EPS15 homology domain of human EPS15, NMR, 20 structures
1FF1 Structure of the second EPS15 homology domain of human EPS15 in complex with ptgssstnpfl
2JXC Structure of the EPS15-EH2 Stonin2 Complex

Browse structure collections

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