1FIB: Gamma-fibrinogen carboxyl terminal fragment

Recombinant human gamma-fibrinogen carboxyl terminal fragment (residues 143-411) bound to calcium at PH 6.0. Determined by X-ray diffraction at 2.1 Å resolution. Released 1 Apr 1997.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,173
Mol. weight: 30.28 kDa
Ligands: CA
Released: 1 Apr 1997

Explore 1FIB in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1FIB contains 9 α-helices and 24 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	145-150	6	1
α-helix	153-158	6
β-strand	165-169	5	1
β-strand	178-184	7	1
β-strand	190-197	8	1
α-helix	208-213	6
β-strand	215-216	2	1
β-strand	226-227	2	1
α-helix	230-238	9
α-helix	239-241	3
β-strand	244-251	8	1
β-strand	257-263	7	1
β-strand	266-267	2	2
α-helix	270-272	3
β-strand	276-277	2	2
β-strand	280-283	4	1
α-helix	289-291	3
α-helix	301-305	5
α-helix	310-312	3
β-strand	313	1	3
β-strand	314	1	4
β-strand	317	1	4
α-helix	326-330	5
β-strand	334	1	3
β-strand	337	1	5
β-strand	339	1	5
β-strand	342-343	2	6
β-strand	347	1	7
β-strand	353	1	8
β-strand	366	1	7
β-strand	368-369	2	6
β-strand	377	1	8
β-strand	381-388	8	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Gamma-fibrinogen carboxyl terminal fragment	A	protein	269	Homo sapiens	P02679 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1FIB_1 GAMMA-FIBRINOGEN CARBOXYL TERMINAL FRAGMENT (chains A)
VQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLDGSV
DFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADY
AMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKF
EGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKT
TMKIIPFNRLTIGEGQQHHLGGAKQAGDV

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	1

Primary citation

Crystal structure of a 30 kDa C-terminal fragment from the gamma chain of human fibrinogen. Yee, V.C., Pratt, K.P., Cote, H.C. et al. Structure (1997) 5:125-138. DOI 10.1016/S0969-2126(97)00171-8 · PubMed

Other PDB entries of the same protein (UniProt P02679 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9KHB 1.03 Å, Crystal structure of wild-type human fibrinogen gamma chain C-terminal domain…
9KHC 1.32 Å, Crystal structure of wild-type human fibrinogen gamma chain C-terminal domain…
2Y7L 1.49 Å, Structure of N-terminal domain of Candida albicans Als9-2 in complex with human…
1DUG 1.8 Å, Structure of the fibrinogen G chain integrin binding and factor xiiia crosslinking sites…
4B60 1.83 Å, Structure of rFnBPA(189-505) in complex with fibrinogen gamma chain C- terminal peptide
2VR3 1.95 Å, Structural and Biochemical Characterization of Fibrinogen binding to ClfA from…
2FIB 2.01 Å, Recombinant human gamma-fibrinogen carboxyl terminal fragment (residues 143-411)…
1FID 2.1 Å, Structure of human gamma fibrinogen 30 kd carboxyl terminal fragment
3FIB 2.1 Å, Recombinant human gamma-fibrinogen carboxyl terminal fragment (residues 143-411) bound…
1FZC 2.3 Å, Crystal structure of fragment double-D from human fibrin with two different bound ligands
3E1I 2.3 Å, Crystal Structure of BbetaD432A Variant Fibrinogen Fragment D with the Peptide Ligand…
2HWL 2.4 Å, Crystal structure of thrombin in complex with fibrinogen gamma' peptide

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