1FIL: Profilin

Human platelet profilin I crystallized in high salt actin-binding protein. Determined by X-ray diffraction at 2.0 Å resolution. Released 8 Nov 1996.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,098
Mol. weight: 15.04 kDa
Released: 8 Nov 1996

Explore 1FIL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1FIL contains 6 α-helices and 7 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	4-11	8
β-strand	16-23	8	1
β-strand	29-33	5	1
α-helix	39-41	3
α-helix	44-50	7
α-helix	57-61	5
β-strand	63-65	3	1
β-strand	68-75	8	1
β-strand	84-89	6	1
β-strand	99-104	6	1
β-strand	108-114	7	1
α-helix	115	1
α-helix	120-135	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Profilin	A	protein	139	Homo sapiens	P07737 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1FIL_1 PROFILIN (chains A)
AGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGVLVGKDRSSFYV
NGLTLGGQKCSVIRDSLLQDGEFSMDLRTKSTGGAPTFNVTVTKTDKTLVLLMGKEGVHG
GLINKKCYEMASHLRRSQY

Primary citation

Crystal Structure of Human Profilin at 2.0 Angstroms Resolution. Fedorov, A.A., Pollard, T.D., Almo, S.C. To be published.

Other PDB entries of the same protein (UniProt P07737 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2PBD 1.5 Å, Ternary complex of profilin-actin with the poly-PRO-GAB domain of VASP*
8BJH 1.69 Å, chimera of the inactive ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo…
8BJJ 1.7 Å, ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to…
8BJI 1.75 Å, chimera of ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo fused to a…
2PAV 1.8 Å, Ternary complex of Profilin-Actin with the Last Poly-Pro of Human VASP
6NBE 2.0 Å, Ternary Complex of Ac-Alpha-Actin with Profilin and CoA-NAA80
4X1L 2.16 Å, Structural basis for mutation-induced destabilization of Profilin 1 in ALS
4X1M 2.17 Å, Structural basis for mutation-induced destabilization of Profilin 1 in ALS
1AWI 2.2 Å, Human platelet profilin complexed with the L-PRO10 peptide
1CF0 2.2 Å, Human platelet profilin complexed with an L-PRO10-iodotyrosine peptide
8BR0 2.22 Å, ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin (residue Q3455…
4X25 2.23 Å, Structural basis for mutation-induced destabilization of Profilin 1 in ALS

Browse structure collections

About this viewer

MolViewer shows 1FIL directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.