1GEA: Receptor-bound conformation of PACAP21

Receptor-bound conformation of PACAP21. Determined by solution NMR. Released 20 Apr 2001.

Method: Solution NMR
Chains: 1
Atoms: 177
Mol. weight: 2.52 kDa
Released: 20 Apr 2001

Explore 1GEA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1GEA contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	9-19	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Pituitary adenylate cyclase activating polypeptide	A	protein	21		P18509 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1GEA_1 PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE (chains A)
HSDGIFTDSYSRYRKQMAVKK

Primary citation

Conformation of a peptide ligand bound to its G-protein coupled receptor. Inooka, H., Ohtaki, T., Kitahara, O. et al. Nat Struct Biol (2001) 8:161-165. DOI 10.1038/84159 · PubMed

Other PDB entries of the same protein (UniProt P18509 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8E3X 2.3 Å, Cryo-EM structure of the PAC1R-PACAP27-Gs complex
8E3Y 2.3 Å, Cryo-EM structure of the VPAC1R-PACAP27-Gs complex
7VQX 2.74 Å, Cryo-EM structure of human vasoactive intestinal polypeptide receptor 2 (VIP2R) in…
27EM 3.0 Å, Cryo_EM structure of PACAP27_PAC1R_Beta_arrestin 1 complex
9P94 3.0 Å, Cryo-EM structure of the PAC1sR-PACAP27-Gs complex
6P9Y 3.01 Å, PAC1 GPCR Receptor complex
6VN7 3.2 Å, Cryo-EM structure of an activated VIP1 receptor-G protein complex
7WBJ 3.42 Å, Cryo-EM structure of N-terminal modified human vasoactive intestinal polypeptide…
6M1I 3.5 Å, CryoEM structure of human PAC1 receptor in complex with PACAP38
6LPB 3.9 Å, Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G…
2D2P The solution structure of micelle-bound peptide
2JOD Pac1-Rshort N-terminal EC domain Pacap(6-38) complex

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