1HLO: Protein

The crystal structure of an intact human max-DNA complex: new insights into mechanisms of transcriptional control. Determined by X-ray diffraction at 2.8 Å resolution. Released 27 Oct 1997.

Method: X-ray diffraction
Resolution: 2.8 Å
Organism: Homo sapiens
Chains: 4
Atoms: 1,746
Mol. weight: 25.79 kDa
Released: 27 Oct 1997

Explore 1HLO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1HLO contains 7 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	4-8	5
α-helix	11-39	29
α-helix	41-43	3
α-helix	50-76	27
α-helix	78-81	4

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	12-39	28
α-helix	50-79	30

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA (5'-d(cpapcpcpapcpgptpgpgp*t)-3')	C	DNA	11
DNA (5'-d(apcpcpapcpgptpgpgptp*g)-3')	D	DNA	11
Protein (transcription factor max)	A, B	protein	80	Homo sapiens	P61244 (AlphaFold model)

Sequence of entity 1 (C), FASTA

>1HLO_1 DNA (5'-D(*CP*AP*CP*CP*AP*CP*GP*TP*GP*GP*T)-3') (chains C)
CACCACGTGGT

Sequence of entity 2 (D), FASTA

>1HLO_2 DNA (5'-D(*AP*CP*CP*AP*CP*GP*TP*GP*GP*TP*G)-3') (chains D)
ACCACGTGGTG

Sequence of entity 3 (A, B), FASTA

>1HLO_3 PROTEIN (TRANSCRIPTION FACTOR MAX) (chains A, B)
NDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQ
YMRRKNHTHQQDIDDLKRQN

Primary citation

The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control. Brownlie, P., Ceska, T., Lamers, M. et al. Structure (1997) 5:509-520. DOI 10.1016/S0969-2126(97)00207-4 · PubMed

Other PDB entries of the same protein (UniProt P61244 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6G6K 1.35 Å, The crystal structures of Human MYC:MAX bHLHZip complex
1NKP 1.8 Å, Crystal structure of Myc-Max recognizing DNA
1NLW 2.0 Å, Crystal structure of Mad-Max recognizing DNA
6G6L 2.2 Å, The crystal structures of Human MYC:MAX bHLHZip complex
6G6J 2.25 Å, The crystal structures of Human MYC:MAX bHLHZip complex
5EYO 2.39 Å, The crystal structure of the Max bHLH domain in complex with 5-carboxyl cytosine DNA
7RCU 2.69 Å, Synthetic Max homodimer mimic in complex with DNA
1AN2 2.9 Å, Recognition by max of its cognate DNA through a dimeric b/hlh/z domain
8OTS 3.3 Å, OCT4 and MYC-MAX co-bound to a nucleosome
8OTT 3.3 Å, MYC-MAX bound to a nucleosome at SHL+5.8
1R05 Solution Structure of Max B-HLH-LZ

Browse structure collections

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