Growth hormone receptor (GHR) is a 638-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P10912.
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The mean pLDDT of this model is 58.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 26% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 51% |
What pLDDT means and how to read it
Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth (PubMed:1549776, PubMed:2825030, PubMed:8943276). On ligand binding, couples to the JAK2/STAT5 pathway (PubMed:1549776, PubMed:15690087, PubMed:2825030, PubMed:8943276)
On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6I5N | X-ray | 1.98 Å | I/J/K/L=591-601 |
| 1AXI | X-ray | 2.1 Å | B=19-254 |
| 1HWG | X-ray | 2.5 Å | B/C=19-255 |
| 1A22 | X-ray | 2.6 Å | B=19-256 |
| 1KF9 | X-ray | 2.6 Å | B/C/E/F=19-256 |
| 2AEW | X-ray | 2.7 Å | A/B=47-251 |
| 3HHR | X-ray | 2.8 Å | B/C=50-254 |
| 6I5J | X-ray | 2.8 Å | I/J/K/L=591-601 |
| 1HWH | X-ray | 2.9 Å | B=19-255 |
| 5OEK | NMR | A/B=254-294 | |
| 5OHD | NMR | A/B=254-294 |
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