1HZN: Cholecystokinin type A receptor

NMR solution structure of the third extracellular loop of the cholecystokinin a receptor. Determined by solution NMR. Released 25 Apr 2001.

Method: Solution NMR
Chains: 1
Atoms: 232
Mol. weight: 3.25 kDa
Released: 25 Apr 2001

Explore 1HZN in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1HZN contains 2 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	5-14	10
α-helix	25-28	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Cholecystokinin type A receptor	A	protein	31		P32238 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1HZN_1 CHOLECYSTOKININ TYPE A RECEPTOR (chains A)
XIFSANAWRAYDTASAERRLSGTPISFILLX

Primary citation

Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin A receptor. Giragossian, C., Mierke, D.F. Biochemistry (2001) 40:3804-3809. DOI 10.1021/bi002659n · PubMed

Other PDB entries of the same protein (UniProt P32238 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7MBX 1.95 Å, Human Cholecystokinin 1 receptor (CCK1R) Gs complex
7MBY 2.44 Å, Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex
7F8Y 2.5 Å, Crystal structure of the cholecystokinin receptor CCKAR in complex with devazepide
9BKK 2.51 Å, Cholecystokinin 1 receptor (CCK1R) sterol 7M mutant, Gq chimera (mGsqi) complex
9BKJ 2.59 Å, Cholecystokinin 1 receptor (CCK1R) Y140A mutant, Gq chimera (mGsqi) complex
7F8U 2.8 Å, Crystal structure of the cholecystokinin receptor CCKAR in complex with lintitript
7EZM 2.9 Å, Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gq complex
7F8X 3.0 Å, Crystal structure of the cholecystokinin receptor CCKAR in complex with NN9056
7XOV 3.0 Å, Structural insights into human brain gut peptide cholecystokinin receptors
7EZK 3.1 Å, Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gs complex
7EZH 3.2 Å, Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gi complex
7XOU 3.2 Å, Structural insights into human brain gut peptide cholecystokinin receptors

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