2D48: Interleukin-4 variant T13D

Crystal structure of the Interleukin-4 variant T13D. Determined by X-ray diffraction at 1.65 Å resolution. Released 30 May 2006.

Method: X-ray diffraction
Resolution: 1.65 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,187
Mol. weight: 15.29 kDa
Released: 30 May 2006

Explore 2D48 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2D48 contains 6 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	6-17	12
α-helix	24-26	3
β-strand	28-30	3	1
α-helix	32-34	3
α-helix	41-59	19
α-helix	70-94	25
β-strand	106-108	3	1
α-helix	109-127	19

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-4	A	protein	129	Homo sapiens	P05112 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2D48_1 Interleukin-4 (chains A)
HKCDITLQEIIKDLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHE
KDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIM
REKYSKCSS

Primary citation

A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor. Kraich, M., Klein, M., Patino, E. et al. BMC Biol (2006) 4:13-13. DOI 10.1186/1741-7007-4-13 · PubMed

Other PDB entries of the same protein (UniProt P05112 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2B8X 1.7 Å, Crystal structure of the interleukin-4 variant F82D
2B8U 1.8 Å, Crystal structure of wildtype human Interleukin-4
2B8Y 1.8 Å, Crystal structure of the interleukin-4 variant T13DF82D
2B91 2.0 Å, Crystal structure of the interleukin-4 variant F82DR85A
4YDY 2.0 Å, Crystal structure of darpin 44C12V5 in complex with human il-4
1HZI 2.05 Å, Interleukin-4 mutant E9A
2B90 2.1 Å, Crystal structure of the interleukin-4 variant T13DR85A
1RCB 2.25 Å, Crystal structure of human recombinant interleukin-4 at 2.25 Å resolution
1IAR 2.3 Å, Interleukin-4 / receptor alpha chain complex
2INT 2.35 Å, Crystal structure of recombinant human interleukin-4
2B8Z 2.5 Å, Crystal structure of the interleukin-4 variant R85A
5FHX 2.55 Å, Crystal structure of codv in complex with IL4 at 2.55 ang. Resolution.

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