1IFG: Ecotin

Crystal structure of a monomeric form of general protease inhibitor, ecotin in absence of a protease. Determined by X-ray diffraction at 2.0 Å resolution. Released 18 May 2001.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Escherichia coli
Chains: 1
Atoms: 1,167
Mol. weight: 15.85 kDa
Released: 18 May 2001

Explore 1IFG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1IFG contains 5 α-helices and 14 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	7-9	3
α-helix	13-16	4
β-strand	20-25	6	1
α-helix	27-29	3
α-helix	33-35	3
β-strand	36-48	13	2
β-strand	53-54	2	1
β-strand	55	1	3
β-strand	56-63	8	1
β-strand	70-82	13	1
β-strand	93-98	6	2
β-strand	99	1	3
α-helix	102-105	4
β-strand	106-108	3	2
β-strand	115-120	6	1
β-strand	124-130A	8	2
β-strand	131-132	2	2
β-strand	137-138	2	2
β-strand	140-141	2	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ecotin	A	protein	140	Escherichia coli	P23827 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1IFG_1 ECOTIN (chains A)
PLEKIAPYPQAEKGMKRQVIQLTPQEDESTLKVELLIGQTLEVDCNLHRLGGKLENKTLE
GWGYDYYVFDKVSSPVSTMMACPDGKKEKKFVTAYLGDAGMLRYNSKLPIVVYTPDNVDV
KYRVWADGKAEEKIDNAVVR

Primary citation

The role of ecotin dimerization in protease inhibition. Eggers, C.T., Wang, S.X., Fletterick, R.J. et al. J Mol Biol (2001) 308:975-991. DOI 10.1006/jmbi.2001.4754 · PubMed

Other PDB entries of the same protein (UniProt P23827 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1SLU 1.8 Å, Rat anionic N143H, E151H trypsin complexed to A86H ecotin
1N8O 2.0 Å, Crystal structure of a complex between bovine chymotrypsin and ecotin
1SLW 2.0 Å, Rat anionic N143H, E151H trypsin complexed to A86H ecotin; nickel-bound
1ECY 2.19 Å, Protease inhibitor ecotin
1FI8 2.2 Å, Rat granzyme B [N66Q] complexed to ecotin [81-84 iepd]
1SLX 2.2 Å, Rat anionic N143H, E151H trypsin complexed to A86H ecotin; zinc-bound
1XX9 2.2 Å, Crystal Structure of the FXIa Catalytic Domain in Complex with EcotinM84R
1AZZ 2.3 Å, Fiddler crab collagenase complexed to ecotin
1EZS 2.3 Å, Crystal structure of ecotin mutant M84R, W67A, G68A, Y69A, D70A bound to rat anionic…
1SLV 2.3 Å, Rat anionic N143H, E151H trypsin complexed to A86H ecotin; copper-bound
1EZU 2.4 Å, Ecotin Y69F, D70P bound to D102N trypsin
7PQN 2.4 Å, Catalytic fragment of MASP-2 in complex with ecotin

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