1IL8: Interleukin 8 in solution

Three-dimensional structure of interleukin 8 in solution. Determined by solution NMR. Released 15 Jan 1991.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 1,164
Mol. weight: 16.8 kDa
Released: 15 Jan 1991

Explore 1IL8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1IL8 contains 4 α-helices and 6 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 2 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	19-21	3
β-strand	22-28	7	1
β-strand	38-43	6	1
β-strand	47-51	5	1
α-helix	56-71	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-8	A, B	protein	72	Homo sapiens	P10145 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>1IL8_1 INTERLEUKIN-8 (chains A, B)
SAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQR
VVEKFLKRAENS

Primary citation

Three-dimensional structure of interleukin 8 in solution. Clore, G.M., Appella, E., Yamada, M. et al. Biochemistry (1990) 29:1689-1696. DOI 10.1021/bi00459a004 · PubMed

Other PDB entries of the same protein (UniProt P10145 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4XDX 0.95 Å, The crystal structure of soluble human interleukin 8 expressed in Pichia pastoris
5D14 1.0 Å, The atomic resolution crystal structure of human IL-8
6N2U 1.25 Å, IL-8 Structure from Bacterial Expression Source
3IL8 2.0 Å, Crystal structure of interleukin 8: symbiosis of NMR and crystallography
1ICW 2.01 Å, Interleukin-8, mutant with glu 38 replaced by cys and cys 50 replaced by ala
9YIP 2.2 Å, Crystal structure of human IL-8 in a large unit cell
6WZM 2.28 Å, LY3041658 Fab bound to CXCL8
1QE6 2.35 Å, Interleukin-8 with an added disulfide between residues 5 and 33 (L5C/H33C)
8XX6 2.99 Å, Structure of CXCR2 bound to CXCL8 (CXCR2-CXCL8-Go Full map)
8XWN 3.29 Å, Structure of CXCR2 bound to CXCL8 (Ligand-receptor focused map)
6LFO 3.4 Å, Cryo-EM structure of a class A GPCR monomer
8IC0 3.41 Å, Cryo-EM structure of CXCL8 bound C-X-C chemokine receptor 1 in complex with Gi…

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