1J6Z: Uncomplexed actin

Uncomplexed actin. Determined by X-ray diffraction at 1.54 Å resolution. Released 15 Aug 2001.

Method: X-ray diffraction
Resolution: 1.54 Å
Organism: Oryctolagus cuniculus
Chains: 1
Atoms: 3,350
Mol. weight: 43.03 kDa
Ligands: RHO, ADP, CA
Released: 15 Aug 2001

Explore 1J6Z in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1J6Z contains 24 α-helices and 19 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 24 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	8-12	5	1
β-strand	16-21	6	1
β-strand	29-32	4	1
β-strand	35-37	3	2
α-helix	41-46	6
β-strand	53-54	2	2
α-helix	56-60	5
β-strand	62	1	3
β-strand	65	1	3
β-strand	66-68	3	2
α-helix	79-88	10
α-helix	89-93	5
α-helix	98-100	3
β-strand	103-107	5	1
α-helix	113-125	13
β-strand	131-136	6	1
α-helix	137-144	8
β-strand	150-155	6	4
β-strand	160-166	7	4
β-strand	169-170	2	4
α-helix	172-174	3
β-strand	176-178	3	4
α-helix	182-194	13
α-helix	203-216	14
α-helix	223-230	8
β-strand	238-241	4	5
β-strand	247-250	4	5
α-helix	253-259	7
α-helix	264-267	4
α-helix	272-273	2
α-helix	274-282	9
α-helix	287-289	3
α-helix	290-294	5
β-strand	297-300	4	4
α-helix	302-304	3
α-helix	309-320	12
β-strand	329-330	2	4
α-helix	335-337	3
α-helix	338-347	10
α-helix	350-355	6
β-strand	357-358	2	1
α-helix	359-365	7
α-helix	367-370	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Actin alpha 1	A	protein	375	Oryctolagus cuniculus	P68135 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1J6Z_1 ACTIN ALPHA 1 (chains A)
DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMT
QIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDL
AGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQ
EYDEAGPSIVHRKCF

Ligands and cofactors

ID	Name	Formula	Copies
RHO	Tetramethylrhodamine-5-maleimide	C28 H25 N3 O5	1
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	1
CA	Calcium ion	Ca	6

Primary citation

The crystal structure of uncomplexed actin in the ADP state. Otterbein, L.R., Graceffa, P., Dominguez, R. Science (2001) 293:708-711. DOI 10.1126/science.1059700 · PubMed

Other PDB entries of the same protein (UniProt P68135 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4B1Y 1.29 Å, Structure of the Phactr1 RPEL-3 bound to G-actin
2FXU 1.35 Å, X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.
4K41 1.4 Å, Crystal structure of actin in complex with marine macrolide kabiramide C
1QZ5 1.45 Å, Structure of rabbit actin in complex with kabiramide C
1WUA 1.45 Å, The structure of Aplyronine A-actin complex
2Q0U 1.45 Å, Structure of Pectenotoxin-2 and Latrunculin B Bound to Actin
2V52 1.45 Å, Structure of MAL-RPEL2 complexed to G-actin
3MN5 1.5 Å, Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation
2PBD 1.5 Å, Ternary complex of profilin-actin with the poly-PRO-GAB domain of VASP*
5ZZA 1.53 Å, OdinProfilin/Rabbit Actin Complex
1QZ6 1.6 Å, Structure of rabbit actin in complex with jaspisamide A
1S22 1.6 Å, Absolute Stereochemistry of Ulapualide A

Browse more

1J6Z is part of these collections:

Motor proteins and the cytoskeleton

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