1JV5: Anti-blood group A Fv

Anti-blood group A Fv. Determined by X-ray diffraction at 2.2 Å resolution. Released 9 Jan 2002.

Method: X-ray diffraction
Resolution: 2.2 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,802
Mol. weight: 24.69 kDa
Released: 9 Jan 2002

Explore 1JV5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1JV5 contains 5 α-helices and 22 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	4-5	2	1
β-strand	10-13	4	2
β-strand	19-25	7	1
β-strand	33-38	6	2
β-strand	44-49	6	2
β-strand	53-54	2	2
α-helix	55	1
β-strand	62-67	6	1
β-strand	70-75	6	1
α-helix	80-82	3
β-strand	85-90	6	2
α-helix	96	1
β-strand	97-98	2	2
β-strand	102-106	5	2

Chain B: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	304-305	2	3
β-strand	309-312	4	2
β-strand	318-324	7	3
α-helix	329-331	3
β-strand	334-339	6	2
β-strand	345-351	7	2
β-strand	358-360	3	2
β-strand	368-373	6	3
β-strand	378-383	6	3
α-helix	388-390	3
β-strand	392-400	9	2
β-strand	403-408	6	2
β-strand	412-416	5	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ig kappa chain precursor V region	A	protein	107	Homo sapiens	P01594 (AlphaFold model)
Ig chain heavy chain precursor V region	B	protein	117	Homo sapiens

Sequence of entity 1 (A), FASTA

>1JV5_1 Ig kappa chain precursor V region (chains A)
DIQMTQTTSSLSASLGDRVTISCRASQDINNYLNWYQQKPDGTVKLLIHYTSRLHSGVPS
RFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPWTFGGGTKLEIK

Sequence of entity 2 (B), FASTA

>1JV5_2 Ig chain heavy chain precursor V region (chains B)
QVQLQQPGAELVKPGTSVKLSCKASGYNFTSYWINWVKLRPGQGLEWIGDIYPGSGITNY
NEKFKSKATLTVDTSSSTAYMQLSSLASEDSALYYCAGQYGNLWFAYWGQGTLVTVS

Primary citation

Structure of an anti-blood group A Fv and improvement of its binding affinity without loss of specificity. Thomas, R., Patenaude, S.I., MacKenzie, C.R. et al. J Biol Chem (2002) 277:2059-2064. DOI 10.1074/jbc.M104364200 · PubMed

Other PDB entries of the same protein (UniProt P01594 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2Q20 1.3 Å, Structure of the germline Vk1 O18/O8 light chain variable domain homodimer
3CDC 1.53 Å, kI O18/O8 N34I/Y87H immunoglobulin light chain variable domain
3CDF 1.53 Å, kI O18/O8 Y87H immunoglobulin light chain variable domain
1B0W 1.8 Å, Structural comparison of amyloidogenic light chain dimer in two crystal forms with…
1QP1 2.06 Å, Kappa variable light chain
3CDY 2.43 Å, AL-09 H87Y, immunoglobulin light chain variable domain
7CZQ 2.8 Å, S protein of SARS-CoV-2 in complex bound with P2B-1A10
4K07 2.83 Å, Crystal structure of the amyloid-forming immunoglobulin AL-103 cis-proline 95 mutant
7CZV 3.3 Å, S protein of SARS-CoV-2 in complex bound with P5A-1B6_3B
7CZU 3.4 Å, S protein of SARS-CoV-2 in complex bound with P5A-1B6_2B

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