1KBH: Nuclear receptor coactivator

Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR. Determined by solution NMR. Released 6 Feb 2002.

Method: Solution NMR
Organisms: Homo sapiens, Mus musculus
Chains: 2
Atoms: 818
Mol. weight: 11.67 kDa
Released: 6 Feb 2002

Explore 1KBH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1KBH contains 7 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	5-16	12
α-helix	25-31	7
α-helix	34-40	7
α-helix	42-44	3

Chain B: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	56-65	10
α-helix	75-80	6
α-helix	84-99	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
nuclear receptor coactivator	A	protein	47	Homo sapiens	Q9Y6Q9 (AlphaFold model)
Creb-binding protein	B	protein	59	Mus musculus	P45481 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1KBH_1 nuclear receptor coactivator (chains A)
EGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPK

Sequence of entity 2 (B), FASTA

>1KBH_2 CREB-BINDING PROTEIN (chains B)
PNRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQ

Primary citation

Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Demarest, S.J., Martinez-Yamout, M., Chung, J. et al. Nature (2002) 415:549-553. DOI 10.1038/415549a · PubMed

Other PDB entries of the same protein (UniProt Q9Y6Q9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3L3X 1.55 Å, Crystal structure of DHT-bound androgen receptor in complex with the first motif of…
9HFW 1.7 Å, SRC-3 (NCoA-3) peptide bound to SPOP MATH domain
3L3Z 2.0 Å, Crystal structure of DHT-bound androgen receptor in complex with the third motif of…
6SQC 2.28 Å, Crystal structure of complex between nuclear coactivator binding domain of CBP and…
6ES7 Structure and dynamics conspire in the evolution of affinity between intrinsically…

Browse structure collections

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