1LB6: TRAF6-CD40 Complex

TRAF6-CD40 Complex. Determined by X-ray diffraction at 1.8 Å resolution. Released 31 Jul 2002.

Method: X-ray diffraction
Resolution: 1.8 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,462
Mol. weight: 19.81 kDa
Released: 31 Jul 2002

Explore 1LB6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1LB6 contains 6 α-helices and 13 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	351-357	7	1
α-helix	360-368	9
β-strand	373-376	4	2
α-helix	377-379	3
β-strand	380-381	2	2
β-strand	388-395	8	2
β-strand	406-414	9	2
α-helix	419-421	3
β-strand	429-434	6	1
β-strand	446-451	6	1
α-helix	457-459	3
α-helix	461-462	2
β-strand	466	1	2
β-strand	469-478	10	2
α-helix	479-483	5
β-strand	489	1	3
β-strand	492	1	3
β-strand	493-500	8	1

Chain B: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	605-608	4	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
TNF receptor-associated factor 6	A	protein	160	Homo sapiens	Q9Y4K3 (AlphaFold model)
CD40 antigen	B	protein	9	Homo sapiens	P25942 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1LB6_1 TNF receptor-associated factor 6 (chains A)
QQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANY
ISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPR
NPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDLE

Sequence of entity 2 (B), FASTA

>1LB6_2 CD40 antigen (chains B)
KQEPQEIDF

Primary citation

Distinct molecular mechanism for initiating TRAF6 signalling. Ye, H., Arron, J.R., Lamothe, B. et al. Nature (2002) 418:443-447. DOI 10.1038/nature00888 · PubMed

Other PDB entries of the same protein (UniProt Q9Y4K3 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3HCT 2.1 Å, Crystal structure of TRAF6 in complex with Ubc13 in the P1 space group
6A33 2.1 Å, Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA
3HCS 2.2 Å, Crystal structure of the N-terminal domain of TRAF6
1LB4 2.4 Å, TRAF6 apo structure
1LB5 2.4 Å, TRAF6-RANK Complex
3HCU 2.6 Å, Crystal structure of TRAF6 in complex with Ubc13 in the C2 space group
5ZUJ 2.6 Å, Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA
8HZ2 2.6 Å, Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) N-terminal Domain
7L3L 2.8 Å, Structure of TRAF5 and TRAF6 RING Hetero dimer
4Z8M 2.95 Å, Crystal structure of the MAVS-TRAF6 complex
2ECI Solution structure of the RING domain of the human TNF receptor-associated factor 6…
2JMD Solution Structure of the Ring Domain of Human TRAF6

Browse structure collections

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