Crystal Structure of the Complex of Subtilisin BPN' with Chymotrypsin Inhibitor 2 at 1.5 Angstrom Resolution. Determined by X-ray diffraction at 1.5 Å resolution. Released 21 Aug 2002.
Explore 1LW6 in 3D Show helices and sheets RCSB PDB PDBe
1LW6 contains 13 α-helices and 24 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 6-10 | 5 | |
| α-helix | 13-18 | 6 | |
| β-strand | 27-32 | 6 | 1 |
| β-strand | 44-49 | 6 | 1 |
| α-helix | 64-73 | 10 | |
| β-strand | 89-94 | 6 | 1 |
| β-strand | 101-102 | 2 | 2 |
| α-helix | 104-116 | 13 | |
| β-strand | 121-124 | 4 | 1 |
| β-strand | 126-127 | 2 | 2 |
| β-strand | 128 | 1 | 3 |
| α-helix | 133-144 | 12 | |
| β-strand | 148-152 | 5 | 1 |
| β-strand | 167 | 1 | 3 |
| β-strand | 175-180 | 6 | 1 |
| α-helix | 185 | 1 | |
| β-strand | 186 | 1 | 1 |
| α-helix | 187 | 1 | |
| β-strand | 198-201 | 4 | 1 |
| β-strand | 205-209 | 5 | 4 |
| β-strand | 213-217 | 5 | 4 |
| α-helix | 220-237 | 18 | |
| α-helix | 243-251 | 9 | |
| β-strand | 255 | 1 | 1 |
| α-helix | 260-263 | 4 | |
| β-strand | 267 | 1 | 1 |
| α-helix | 270-275 | 6 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 23 | 1 | 5 |
| α-helix | 25-27 | 3 | |
| β-strand | 31 | 1 | 6 |
| α-helix | 32-42 | 11 | |
| β-strand | 47-52 | 6 | 5 |
| β-strand | 56-58 | 3 | 2 |
| β-strand | 65-70 | 6 | 5 |
| β-strand | 75 | 1 | 6 |
| β-strand | 76 | 1 | 5 |
| β-strand | 81-82 | 2 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Subtilisin bpn' | E | protein | 281 | Bacillus amyloliquefaciens | P00782 (AlphaFold model) |
| Subtilisin-chymotrypsin inhibitor-2A | I | protein | 64 | Hordeum vulgare | P01053 (AlphaFold model) |
>1LW6_1 SUBTILISIN BPN' (chains E) AQSVPYGVSQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLKVAGGASMVPSETNPFQD NNSHGTHVAGTVAALNNSIGVLGVAPSASLYAVKVLGADGSGQYSWIINGIEWAIANNMD VINMSLGGPSGSAALKAAVDKAVASGVVVVAAAGNEGTSGSSSTVGYPGKYPSVIAVGAV DSSNQRASFSSVGPELDVMAPGVSIQSTLPGNKYGAYNGTSMASPHVAGAAALILSKHPN WTNTQVRSSLENTTTKLGDSFYYGKGLINVQAAAQHHHHHH
>1LW6_2 SUBTILISIN-CHYMOTRYPSIN INHIBITOR-2A (chains I) MKTEWPELVGKSVEEAKKVILQDKPAAQIIVLPVGTIVTMEYRIDRVRLFVDKLDNIAQV PRVG
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 1 |
Water and common crystallization additives (SO4) are not listed.
A clogged gutter mechanism for protease inhibitors. Radisky, E.S., Koshland Jr., D.E. Proc Natl Acad Sci U S A (2002) 99:10316-10321. DOI 10.1073/pnas.112332899 · PubMed
Other PDB entries of the same protein (UniProt P00782 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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