1M4E: Hepcidin-20

Solution Structure of Hepcidin-20. Determined by solution NMR. Released 6 Nov 2002.

Method: Solution NMR
Chains: 1
Atoms: 144
Mol. weight: 2.2 kDa
Released: 6 Nov 2002

Explore 1M4E in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1M4E contains 0 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 0 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	3-6	4	1
β-strand	14-17	4	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Hepcidin	A	protein	20		P81172 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1M4E_1 Hepcidin (chains A)
ICIFCCGCCHRSKCGMCCKT

Primary citation

The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. Hunter, H.N., Fulton, D.B., Ganz, T. et al. J Biol Chem (2002) 277:37597-37603. DOI 10.1074/jbc.M205305200 · PubMed

Other PDB entries of the same protein (UniProt P81172 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3H0T 1.89 Å, Hepcidin-Fab complex
4QAE 2.1 Å, Crystal structure of an engineered lipocalin (Anticalin) in complex with human hepcidin
6WBV 2.5 Å, Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc
1M4F Solution Structure of Hepcidin-25
2KEF Solution NMR structures of human hepcidin at 325K

Browse structure collections

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