1MSH: Human melanoma growth stimulatory activity

Solution structure of gro(slash)melanoma growth stimulatory activity determined by 1H NMR spectroscopy. Determined by solution NMR. Released 31 Mar 1995.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 1,078
Mol. weight: 15.53 kDa
Released: 31 Mar 1995

Explore 1MSH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1MSH contains 4 α-helices and 10 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	3-5	3
β-strand	15	1	1
β-strand	25-29	5	2
β-strand	41-43	3	2
β-strand	49-51	3	2
β-strand	52	1	1
α-helix	57-67	11

Chain B: 2 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	3-5	3
β-strand	15	1	3
β-strand	25-29	5	2
β-strand	39-43	5	2
β-strand	49-51	3	2
β-strand	52	1	3
α-helix	57-67	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Human melanoma growth stimulatory activity	A, B	protein	72	Homo sapiens	P09341 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>1MSH_1 HUMAN MELANOMA GROWTH STIMULATORY ACTIVITY (chains A, B)
ASVATELRCQCLQTLQGIHPKNIQSVNVKSPGPHCAQTEVIATLKNGRKACLNPASPIVK
KIIEKMLNSDKS

Primary citation

Solution structure of GRO/melanoma growth stimulatory activity determined by 1H NMR spectroscopy. Kim, K.S., Clark-Lewis, I., Sykes, B.D. J Biol Chem (1994) 269:32909-32915. PubMed

Other PDB entries of the same protein (UniProt P09341 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9EJC 2.98 Å, Cryo-EM Structure of CXCL1-KSHV ORF74-Gi-scFv16 Complex
8K4O 3.01 Å, Cryo-EM structure of Kaposi's Sarcoma-Associated Herpesvirus-G Protein-Coupled Receptor…
8XWV 3.07 Å, Structure of CXCR2 bound to CXCL1 (CXCR2-CXCL1-Go Full map)
8XWA 3.48 Å, Structure of CXCR2 bound to CXCL1 (Ligand-receptor focused map)
1MGS The solution structure of melanoma growth stimulating activity
1MSG Solution structure of gro(slash)melanoma growth stimulatory activity determined by 1H…
1ROD Chimeric protein of interleukin 8 and human melanoma growth stimulating activity…

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