1MWE: Complex of tern N9 influenza virus neuraminidase

The X-ray structure of a complex of tern N9 influenza virus neuraminidase complexed with sialic acid at 4 degrees C revealing a second sialic acid binding site. Determined by X-ray diffraction at 1.7 Å resolution. Released 4 Mar 1998.

Method: X-ray diffraction
Resolution: 1.7 Å
Organism: Influenza A virus
Chains: 1
Atoms: 3,654
Mol. weight: 46.65 kDa
Ligands: NAG, SIA, CA
Released: 4 Mar 1998

Explore 1MWE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1MWE contains 6 α-helices and 29 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	89-90	2
β-strand	91	1	1
α-helix	92-93	2
β-strand	96-102	7	2
α-helix	105-109	5
β-strand	114	1	3
β-strand	115-125	11	4
β-strand	128-139	12	4
α-helix	143-145	3
β-strand	157-162	6	4
β-strand	168	1	3
β-strand	172-176	5	4
β-strand	179-184	6	5
β-strand	189-195	7	5
β-strand	202-207	6	5
β-strand	210-216	7	5
β-strand	224	1	6
β-strand	233	1	6
β-strand	236-244	9	6
β-strand	250-258	9	6
β-strand	261-267	7	6
β-strand	276-283	8	7
β-strand	286-292	7	7
α-helix	300	1
β-strand	301-306	6	7
β-strand	311-316	6	7
β-strand	353-354	2	8
β-strand	361-364	4	8
β-strand	372-378	7	8
β-strand	392-403	11	8
β-strand	407-411	5	2
β-strand	418	1	1
β-strand	420-429	10	2
β-strand	439-449	11	2
α-helix	464-467	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Neuraminidase	A	protein	388	Influenza A virus	P03472

Sequence of entity 1 (A), FASTA

>1MWE_1 NEURAMINIDASE (chains A)
RDFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRFYALSQGTTIR
GKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSSTSCHDGKTRMSICISGPNNN
ASAVIWYNRRPVTEINTWARNILRTQESECVCHNGVCPVVFTDGSATGPAETRIYYFKEG
KILKWEPLAGTAKHIEECSCYGERAEITCTCRDNWQGSNRPVIRIDPVAMTHTSQYICSP
VLTDNPRPNDPTVGKCNDPYPGNNNNGVKGFSYLDGVNTWLGRTISIASRSGYEMLKVPN
ALTDDKSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGRPKEDKVWWTS
NSIVSMCSSTEFLGQWDWPDGAKIEYFL

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	3
SIA	N-acetyl-alpha-neuraminic acid	C11 H19 N O9	2
CA	Calcium ion	Ca	2

Primary citation

Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases. Varghese, J.N., Colman, P.M., van Donkelaar, A. et al. Proc Natl Acad Sci U S A (1997) 94:11808-11812. DOI 10.1073/pnas.94.22.11808 · PubMed

Other PDB entries of the same protein (UniProt P03472), best resolution first:

6HFC 1.29 Å, Influenza A Virus N9 Neuraminidase Native (Tern).
6HCX 1.3 Å, Influenza Virus N9 Neuraminidase A complex with Zanamivir molecule (Tern).
6HG0 1.3 Å, Influenza A Virus N9 Neuraminidase complex with NANA (Tern/Australia).
1F8D 1.4 Å, Native Influenza Neuraminidase in Complex with 9-amino-2-deoxy-2,3-dehydro-N-neuraminic…
1F8E 1.4 Å, Native Influenza Neuraminidase in Complex with 4,9-diamino-2-deoxy-2,3-dehydro-N-acetyl-n…
6D3B 1.4 Å, Influenza virus neuraminidase subtype N9 (TERN) apo form
4DGR 1.55 Å, Influenza Subtype 9 Neuraminidase Benzoic Acid Inhibitor Complex
2QWC 1.6 Å, The X-ray structure of a complex of NEU5AC2EN and a drug resistant variant R292K of tern…
1F8C 1.7 Å, Native Influenza Neuraminidase in Complex with 4-amino-2-deoxy-2,3-dehydro-N-neuraminic…
2QWA 1.7 Å, The X-ray structure of a drug resistant variant R292K of tern N9 influenza virus…
6HEB 1.75 Å, Influenza A Virus N9 Neuraminidase complex with Oseltamivir (Tern).
1F8B 1.8 Å, Native Influenza Virus Neuraminidase in Complex with NEU5AC2EN

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