1OI1: MBT domains of Human SCML2

Crystal Structure of the MBT domains of Human SCML2. Determined by X-ray diffraction at 1.78 Å resolution. Released 15 Jun 2003.

Method: X-ray diffraction
Resolution: 1.78 Å
Organism: HOMO SAPIENS
Chains: 1
Atoms: 1,945
Mol. weight: 24.76 kDa
Released: 15 Jun 2003

Explore 1OI1 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1OI1 contains 13 α-helices and 13 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	35-41	7
β-strand	46	1	1
α-helix	47-48	2
α-helix	49-51	3
α-helix	58-60	3
β-strand	68-73	6	2
β-strand	76-89	14	2
β-strand	92-97	6	2
β-strand	106-109	4	2
β-strand	115-116	2	2
α-helix	120-123	4
α-helix	130-131	2
α-helix	141-149	9
α-helix	152-153	2
β-strand	154	1	2
α-helix	155-156	2
α-helix	157-159	3
α-helix	161-167	7
β-strand	177-181	5	1
β-strand	189-198	10	1
β-strand	201-206	6	1
β-strand	215-218	4	1
β-strand	224-225	2	1
α-helix	229-233	5
β-strand	237	1	1
α-helix	238-240	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
SCML2 protein	A	protein	221	HOMO SAPIENS	Q9UQR0 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1OI1_1 SCML2 PROTEIN (chains A)
GSTSSVQRDDFHWEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDPRNATSVCI
ATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNTSSWP
MFLLETLNGSEMASATLFKKEPPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEV
HITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTS

Primary citation

Crystal Structure of the Malignant Brain Tumor (Mbt) Repeats in Sex Comb on Midleg-Like 2 (Scml2). Sathyamurthy, A., Allen, M.D., Murzin, A.G. et al. J Biol Chem (2003) 278:46968. DOI 10.1074/JBC.M306469200 · PubMed

Other PDB entries of the same protein (UniProt Q9UQR0 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2BIV 1.7 Å, Crystal structure of the wild-type MBT domains of Human SCML2
2VYT 1.9 Å, The MBT repeats of human SCML2 bind to peptides containing mono methylated lysine.
4EDU 2.58 Å, The MBT repeats of human SCML2 in a complex with histone H2A peptide
2MEM Solution NMR structure of SLED domain of Scml2

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