4EDU: Sex comb on midleg-like protein 2

The MBT repeats of human SCML2 in a complex with histone H2A peptide. Determined by X-ray diffraction at 2.58 Å resolution. Released 19 Sept 2012.

Method: X-ray diffraction
Resolution: 2.58 Å
Organism: Homo sapiens
Chains: 2
Atoms: 1,768
Mol. weight: 25.99 kDa
Released: 19 Sept 2012

Explore 4EDU in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4EDU contains 14 α-helices and 13 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	35-42	8
β-strand	46	1	1
α-helix	47-48	2
α-helix	49-51	3
α-helix	58-60	3
β-strand	68-73	6	2
β-strand	76-89	14	2
β-strand	92-97	6	2
β-strand	106-109	4	2
β-strand	115-117	3	2
α-helix	120-124	5
α-helix	126-128	3
α-helix	138-140	3
α-helix	141-149	9
β-strand	154	1	2
α-helix	155-156	2
α-helix	157-159	3
α-helix	161-167	7
β-strand	177-181	5	1
β-strand	189-198	10	1
β-strand	201-206	6	1
α-helix	211-213	3
β-strand	215-218	4	1
β-strand	224-225	2	1
α-helix	229-233	5
β-strand	237	1	1
α-helix	238-240	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Sex comb on midleg-like protein 2	A	protein	215	Homo sapiens	Q9UQR0 (AlphaFold model)
Histone H2A.J peptide	T	protein	16	Homo sapiens	Q9BTM1 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4EDU_1 Sex comb on midleg-like protein 2 (chains A)
QRDDFHWEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGI
TGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNTSSWPMFLLET
LNGSEMASATLFKKEPPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDG
WSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTS

Sequence of entity 2 (T), FASTA

>4EDU_2 Histone H2A.J peptide (chains T)
VHRLLRKGNYAERVGA

Primary citation

Histone recognition by human malignant brain tumor domains. Nady, N., Krichevsky, L., Zhong, N. et al. J Mol Biol (2012) 423:702-718. DOI 10.1016/j.jmb.2012.08.022 · PubMed

Other PDB entries of the same protein (UniProt Q9UQR0 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2BIV 1.7 Å, Crystal structure of the wild-type MBT domains of Human SCML2
1OI1 1.78 Å, Crystal Structure of the MBT domains of Human SCML2
2VYT 1.9 Å, The MBT repeats of human SCML2 bind to peptides containing mono methylated lysine.
2MEM Solution NMR structure of SLED domain of Scml2

Browse structure collections

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