1OW7: Paxillin LD4 motif
Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase. Determined by X-ray diffraction at 2.6 Å resolution. Released 21 Oct 2003.
- Method
- X-ray diffraction
- Resolution
- 2.6 Å
- Organism
- Homo sapiens
- Chains
- 6
- Atoms
- 3,520
- Mol. weight
- 57.82 kDa
- Released
- 21 Oct 2003
Explore 1OW7 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
1OW7 contains 21 α-helices and 0 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 923-941 | 19 | |
| α-helix | 947-971 | 25 | |
| α-helix | 972-974 | 3 | |
| α-helix | 980-1006 | 27 | |
| α-helix | 1013-1046 | 34 | |
Chain B: 8 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 911 | 1 | |
| α-helix | 913-914 | 2 | |
| α-helix | 923-941 | 19 | |
| α-helix | 947-969 | 23 | |
| α-helix | 972-974 | 3 | |
| α-helix | 977-979 | 3 | |
| α-helix | 980-1006 | 27 | |
| α-helix | 1012-1045 | 34 | |
Chain C: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 910-911 | 2 | |
| α-helix | 923-940 | 18 | |
| α-helix | 947-971 | 25 | |
| α-helix | 980-1006 | 27 | |
| α-helix | 1011-1046 | 36 | |
Chain D: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-11 | 7 | |
Chain E: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-9 | 5 | |
Chain F: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-11 | 9 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Focal adhesion kinase 1 | A, B, C | protein | 161 | Homo sapiens | Q05397 (AlphaFold model) |
| Paxillin | D, E, F | protein | 13 | | P49023 (AlphaFold model) |
Sequence of entity 1 (A, B, C), FASTA
>1OW7_1 Focal adhesion kinase 1 (chains A, B, C)
SSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYV
PMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTS
LQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
Sequence of entity 2 (D, E, F), FASTA
>1OW7_2 Paxillin (chains D, E, F)
ATRELDELMASLS
Primary citation
Molecular Recognition of Paxillin LD Motifs by the Focal Adhesion Targeting Domain. Hoellerer, M.K., Noble, M.E.M., Labesse, G. et al. Structure (2003) 11:1207-1217. DOI 10.1016/j.str.2003.08.010 · PubMed
Other PDB entries of the same protein (UniProt Q05397 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6YOJ 1.36 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 6-[4-(3-Methanesulfonyl-benzylamin…
- 6YT6 1.54 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(3-{[2-(2-oxo-2,3-dihyd…
- 4I4E 1.55 Å, Structure of Focal Adhesion Kinase catalytic domain in complex with hinge binding…
- 1MP8 1.6 Å, Crystal structure of Focal Adhesion Kinase (FAK)
- 4EBV 1.67 Å, Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric…
- 4I4F 1.75 Å, Structure of Focal Adhesion Kinase catalytic domain in complex with an allosteric…
- 6YQ1 1.78 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(3-{[2-(2-oxo-1,2,3,4-t…
- 3PXK 1.79 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH Pyrrolo[2,3-d]thiazole
- 6YVS 1.81 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 5-{4-[(Pyridin-3-ylmethyl)-amino]-…
- 6YVY 1.92 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 4-{[4-{[(1R,2R)-2-(dimethylamino)c…
- 6YR9 1.93 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(2-{[2-(2-oxo-2,3-dihyd…
- 7W8I 1.94 Å, Crystal structure of Zn bound human Focal Adhesion Targeting (FAT) domain of the Focal…
Browse structure collections
About this viewer
MolViewer shows 1OW7 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.