Paxillin (PXN) is a 591-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P49023.
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The mean pLDDT of this model is 65.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 42% |
What pLDDT means and how to read it
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion
Interacts in vitro with VCL/vinculin as well as to the SH3 domain of SRC and, when tyrosine phosphorylated, to the SH2 domain of CRK (PubMed:7534286). Interacts with GIT1 (PubMed:10938112). Interacts with NUDT16L1/SDOS (By similarity). Interacts with PTK2/FAK1 (PubMed:14527389). Interacts with PTK2B/PYK2 (PubMed:19358827). Interacts with ASAP2 (PubMed:10749932). Interacts with unphosphorylated…
Cytoplasm, cytoskeleton, Cell junction, focal adhesion, Cytoplasm, cell cortex
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2O9V | X-ray | 1.63 Å | B=45-54 |
| 2VZG | X-ray | 1.8 Å | A=141-160 |
| 6PW8 | X-ray | 1.95 Å | B=141-153 |
| 4XH2 | X-ray | 2.0 Å | a/c/e/g/h/j=259-275 |
| 2VZD | X-ray | 2.1 Å | C/D=1-20 |
| 2VZI | X-ray | 2.2 Å | A=262-277 |
| 5UWH | X-ray | 2.26 Å | D=264-277 |
| 3PY7 | X-ray | 2.29 Å | A=1-10 |
| 1OW6 | X-ray | 2.35 Å | D/F=262-274 |
| 3RQG | X-ray | 2.5 Å | E=262-274 |
| 4XGZ | X-ray | 2.5 Å | a/c/e/g/h/j/m/o/q/s/u/w=141-159 |
| 9QWO | X-ray | 2.54 Å | E/F=140-158 |
| 1OW7 | X-ray | 2.6 Å | D/E/F=262-274 |
| 6IUI | X-ray | 2.6 Å | C/D=261-278 |
| 3RQF | X-ray | 2.7 Å | E=141-153 |
| 3RQE | X-ray | 2.8 Å | E=2-15 |
| 1OW8 | X-ray | 2.85 Å | D/F=141-153 |
| 4EDN | X-ray | 2.9 Å | K/L/M/N/O/P/Q=1-20 |
| 3GM1 | X-ray | 2.95 Å | C/D/E/F=262-274 |
| 3U3F | X-ray | 3.1 Å | E/F/G/H/I/J=261-277 |
Showing 20 of 25 experimental structures (best resolution first).
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