1OW8: Paxillin LD2 motif

Paxillin LD2 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase. Determined by X-ray diffraction at 2.85 Å resolution. Released 21 Oct 2003.

Method: X-ray diffraction
Resolution: 2.85 Å
Organism: Homo sapiens
Chains: 5
Atoms: 3,472
Mol. weight: 56.6 kDa
Released: 21 Oct 2003

Explore 1OW8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1OW8 contains 22 α-helices and 0 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	923-941	19
α-helix	947-971	25
α-helix	972-974	3
α-helix	977-979	3
α-helix	980-1006	27
α-helix	1013-1046	34

Chain B: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	911	1
α-helix	914	1
α-helix	923-941	19
α-helix	947-969	23
α-helix	972-974	3
α-helix	977-979	3
α-helix	980-1006	27
α-helix	1013-1045	33

Chain C: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	910-911	2
α-helix	923-940	18
α-helix	947-969	23
α-helix	977-979	3
α-helix	980-1006	27
α-helix	1011-1046	36

Chains D and F: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3-12	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Focal adhesion kinase 1	A, B, C	protein	161	Homo sapiens	Q05397 (AlphaFold model)
Paxillin	D, F	protein	13		P49023 (AlphaFold model)

Sequence of entity 1 (A, B, C), FASTA

>1OW8_1 Focal adhesion kinase 1 (chains A, B, C)
SSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYV
PMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTS
LQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH

Sequence of entity 2 (D, F), FASTA

>1OW8_2 Paxillin (chains D, F)
NLSELDRLLLELN

Primary citation

Molecular Recognition of Paxillin LD Motifs by the Focal Adhesion Targeting Domain. Hoellerer, M.K., Noble, M.E.M., Labesse, G. et al. Structure (2003) 11:1207-1217. DOI 10.1016/j.str.2003.08.010 · PubMed

Other PDB entries of the same protein (UniProt Q05397 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6YOJ 1.36 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 6-[4-(3-Methanesulfonyl-benzylamin…
6YT6 1.54 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(3-{[2-(2-oxo-2,3-dihyd…
4I4E 1.55 Å, Structure of Focal Adhesion Kinase catalytic domain in complex with hinge binding…
1MP8 1.6 Å, Crystal structure of Focal Adhesion Kinase (FAK)
4EBV 1.67 Å, Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric…
4I4F 1.75 Å, Structure of Focal Adhesion Kinase catalytic domain in complex with an allosteric…
6YQ1 1.78 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(3-{[2-(2-oxo-1,2,3,4-t…
3PXK 1.79 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH Pyrrolo[2,3-d]thiazole
6YVS 1.81 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 5-{4-[(Pyridin-3-ylmethyl)-amino]-…
6YVY 1.92 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 4-{[4-{[(1R,2R)-2-(dimethylamino)c…
6YR9 1.93 Å, FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH N-Methyl-N-(2-{[2-(2-oxo-2,3-dihyd…
7W8I 1.94 Å, Crystal structure of Zn bound human Focal Adhesion Targeting (FAT) domain of the Focal…

Browse structure collections

About this viewer

MolViewer shows 1OW8 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.