1QX7: ApoCaM
Crystal structure of apoCaM bound to the gating domain of small conductance Ca2+-activated potassium channel. Determined by X-ray diffraction at 3.09 Å resolution. Released 31 Aug 2004.
- Method
- X-ray diffraction
- Resolution
- 3.09 Å
- Organism
- Rattus norvegicus
- Chains
- 6
- Atoms
- 5,523
- Mol. weight
- 95.93 kDa
- Released
- 31 Aug 2004
Explore 1QX7 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
1QX7 contains 41 α-helices and 18 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 7 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-18 | 13 | |
| β-strand | 26-27 | 2 | 4 |
| α-helix | 29-37 | 9 | |
| β-strand | 63-64 | 2 | 4 |
| α-helix | 65-75 | 11 | |
| α-helix | 81-89 | 9 | |
| β-strand | 99-101 | 3 | 5 |
| α-helix | 102-111 | 10 | |
| α-helix | 118-127 | 10 | |
| β-strand | 135-137 | 3 | 6 |
| α-helix | 138-145 | 8 | |
Chain B: 8 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-17 | 12 | |
| β-strand | 26 | 1 | 7 |
| α-helix | 29-37 | 9 | |
| α-helix | 45-50 | 6 | |
| β-strand | 64 | 1 | 7 |
| α-helix | 65-75 | 11 | |
| α-helix | 81-90 | 10 | |
| β-strand | 99-101 | 3 | 6 |
| α-helix | 102-110 | 9 | |
| α-helix | 118-127 | 10 | |
| β-strand | 135-137 | 3 | 5 |
| α-helix | 138-143 | 6 | |
Chain D: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 431-439 | 9 | |
Chain I: 11 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-18 | 13 | |
| β-strand | 27-28 | 2 | 1 |
| α-helix | 29-37 | 9 | |
| α-helix | 47-54 | 8 | |
| β-strand | 62-63 | 2 | 1 |
| α-helix | 65-75 | 11 | |
| α-helix | 76-78 | 3 | |
| α-helix | 81-91 | 11 | |
| β-strand | 99-101 | 3 | 2 |
| α-helix | 102-107 | 6 | |
| α-helix | 108-112 | 5 | |
| α-helix | 113-115 | 3 | |
| α-helix | 118-127 | 10 | |
| β-strand | 135-137 | 3 | 3 |
| α-helix | 138-145 | 8 | |
Chain M: 6 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-16 | 11 | |
| β-strand | 27 | 1 | 8 |
| α-helix | 29-37 | 9 | |
| β-strand | 63 | 1 | 8 |
| α-helix | 65-68 | 4 | |
| α-helix | 85-88 | 4 | |
| β-strand | 99 | 1 | 9 |
| α-helix | 118-127 | 10 | |
| β-strand | 137 | 1 | 9 |
| α-helix | 138-145 | 8 | |
Chain R: 8 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-18 | 13 | |
| α-helix | 29-37 | 9 | |
| α-helix | 45-54 | 10 | |
| α-helix | 65-76 | 12 | |
| α-helix | 81-91 | 11 | |
| β-strand | 99-101 | 3 | 3 |
| α-helix | 102-115 | 14 | |
| α-helix | 118-127 | 10 | |
| β-strand | 135-137 | 3 | 2 |
| α-helix | 138-145 | 8 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Calmodulin | A, B, I, M, R | protein | 148 | Rattus norvegicus | P0DP29 (AlphaFold model) |
| Small conductance calcium-activated potassium channel protein 2 | D | protein | 85 | Rattus norvegicus | P70604 (AlphaFold model) |
Sequence of entity 1 (A, B, I, M, R), FASTA
>1QX7_1 Calmodulin (chains A, B, I, M, R)
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK
Sequence of entity 2 (D), FASTA
>1QX7_2 Small conductance calcium-activated potassium channel protein 2 (chains D)
MMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQ
RKLNDQANTLVDLAKTQLEHHHHHH
Primary citation
Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex. Schumacher, M.A., Crum, M., Miller, M.C. Structure (2004) 12:849-860. DOI 10.1016/j.str.2004.03.017 · PubMed
Other PDB entries of the same protein (UniProt P0DP29 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 2PQ3 1.3 Å, N-Terminal Calmodulin Zn-Trapped Intermediate
- 4J9Y 1.51 Å, Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance…
- 1G4Y 1.6 Å, 1.60 a crystal structure of the gating domain from small conductance potassium channel…
- 3B32 1.6 Å, Crystal Structure of Calcium-Saturated Calmodulin N-Terminal Domain Fragment, Residues…
- 4G28 1.63 Å, Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance…
- 4G27 1.65 Å, Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance…
- 4J9Z 1.66 Å, Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance…
- 9M6G 1.7 Å, the crystal structure of the Ca2+/CaM-CASK-CaMK-Mint1-CID complex
- 9KYS 1.76 Å, the Ca2+/CaM-CASK-ARD complex
- 6MBA 1.8 Å, Crystal Structure of Human Nav1.4 CTerminal Domain in Complex with apo Calmodulin
- 9M5Y 1.8 Å, the crystal structure of the Ca2+/CaM-CASK-CaMK complex
- 9U9D 1.8 Å, Bipartite Genetically Encoded Biosensor sG-GECO1
Browse structure collections
About this viewer
MolViewer shows 1QX7 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.