1R02: Orexin-A

Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness. Determined by solution NMR. Released 19 Sept 2004.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 248
Mol. weight: 3.59 kDa
Released: 19 Sept 2004

Explore 1R02 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1R02 contains 2 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	14-21	8
α-helix	25-31	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Orexin-A	A	protein	33	Homo sapiens	O43612 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1R02_1 Orexin-A (chains A)
QPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL

Primary citation

Solution structure of human orexin-A: regulator of appetite and wakefulness. Kim, H.Y., Hong, E., Kim, J.I. et al. J Biochem Mol Biol (2004) 37:565-573. DOI 10.5483/BMBRep.2004.37.5.565 · PubMed

Other PDB entries of the same protein (UniProt O43612 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1UVQ 1.8 Å, Crystal structure of HLA-DQ0602 in complex with a hypocretin peptide
7L1U 3.2 Å, Orexin Receptor 2 (OX2R) in Complex with G Protein and Natural Peptide-Agonist Orexin B…
1CQ0 Solution structure of a human hypocretin-2/OREXIN-b'solution structure of a human…
1WSO The solution structures of human Orexin-A

Browse structure collections

About this viewer

MolViewer shows 1R02 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.