Structure of the heterodimer of the conserved GTPase domains of the Signal Recognition Particle (Ffh) and Its Receptor (FtsY). Determined by X-ray diffraction at 1.9 Å resolution. Released 27 Jan 2004.
Explore 1RJ9 in 3D Show helices and sheets RCSB PDB PDBe
1RJ9 contains 25 α-helices and 20 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 28-41 | 14 | |
| α-helix | 46-58 | 13 | |
| α-helix | 66-72 | 7 | |
| α-helix | 81-87 | 7 | |
| β-strand | 104-108 | 5 | 1 |
| α-helix | 115-127 | 13 | |
| β-strand | 133-136 | 4 | 1 |
| α-helix | 147-156 | 10 | |
| β-strand | 160-161 | 2 | 1 |
| α-helix | 169-183 | 15 | |
| β-strand | 187-190 | 4 | 1 |
| α-helix | 200-216 | 17 | |
| β-strand | 223-229 | 7 | 1 |
| β-strand | 232 | 1 | 2 |
| α-helix | 235-247 | 13 | |
| β-strand | 251-255 | 5 | 1 |
| α-helix | 266-273 | 8 | |
| α-helix | 275-276 | 2 | |
| β-strand | 277-281 | 5 | 1 |
| β-strand | 289-291 | 3 | 1 |
| α-helix | 294-301 | 8 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 21 | 1 | 3 |
| α-helix | 22-23 | 2 | |
| α-helix | 30-40 | 11 | |
| α-helix | 45-59 | 15 | |
| β-strand | 63 | 1 | 3 |
| α-helix | 70-86 | 17 | |
| β-strand | 99-104 | 6 | 4 |
| α-helix | 111-123 | 13 | |
| β-strand | 129-133 | 5 | 4 |
| α-helix | 141-152 | 12 | |
| β-strand | 156-158 | 3 | 4 |
| α-helix | 159-160 | 2 | |
| α-helix | 165-178 | 14 | |
| β-strand | 183-187 | 5 | 4 |
| α-helix | 188-190 | 3 | |
| α-helix | 196-209 | 14 | |
| β-strand | 213-219 | 7 | 4 |
| β-strand | 222 | 1 | 2 |
| α-helix | 226-237 | 12 | |
| β-strand | 241-245 | 5 | 4 |
| α-helix | 255-263 | 9 | |
| β-strand | 267-271 | 5 | 4 |
| β-strand | 279-281 | 3 | 4 |
| α-helix | 284-292 | 9 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Signal Recognition Protein | A | protein | 304 | Thermus aquaticus | P83749 (AlphaFold model) |
| Signal recognition particle protein | B | protein | 300 | Thermus aquaticus | O07347 (AlphaFold model) |
>1RJ9_1 Signal Recognition Protein (chains A) MGFFDRLKAGLAKTRERLLKAIPWGGNLEEVLEELEMALLAADVGLSATEEILQEVRASG RKDLKEAVKEKLVGMLEPDERRATLRKLGFNPQKPKPVEPKGRVVLVVGVNGVGKTTTIA KLGRYYQNLGKKVMFCAGDTFRAAGGTQLSEWGKRLSIPVIQGPEGTDSAALAYDAVQAM KARGYDLLFVDTAGRLHTKHNLMEELKKVKRAIAKADPEEPKEVWLVLDAVTGQNGLEQA KKFHEAVGLTGVIVTKLDGTAKGGVLIPIVRTLKVPIKFVGVGEGPDDLQPFDPEAFVEA LLED
>1RJ9_2 Signal recognition particle protein (chains B) MFQQLSARLQEAIGRLRGRGRITEEDLKATLREIRRALMDADVNLEVTRDFVERVREEAL GKQVLESLTPAEVILATVYEALKEALGGEARLPVLKDRNLWFLVGLQGSGKTTTAAKLAL YYKGKGRRPLLVAADTQRPAAREQLRLLGEKVGVPVLEVMDGESPESIRRRVEEKARLEA RDLILVDTAGRLQIDEPLMGELARLKEVLGPDEVLLVLDAMTGQEALSVARAFDEKVGVT GLVLTKLDGDARGGAALSARHVTGKPIYFAGVSEKPEGLEPFYPERLAGRILGMGDVASL
| ID | Name | Formula | Copies |
|---|---|---|---|
| GCP | Phosphomethylphosphonic acid guanylate ester | C11 H18 N5 O13 P3 | 2 |
| MG | Magnesium ion | Mg | 2 |
Substrate twinning activates the signal recognition particle and its receptor. Egea, P.F., Shan, S.O., Napetschnig, J. et al. Nature (2004) 427:215-221. DOI 10.1038/nature02250 · PubMed
Other PDB entries of the same protein (UniProt P83749 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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