1U6G: Cand1-Cul1-Roc1 Complex

Crystal Structure of The Cand1-Cul1-Roc1 Complex. Determined by X-ray diffraction at 3.1 Å resolution. Released 14 Dec 2004.

Method
X-ray diffraction
Resolution
3.1 Å
Organism
Homo sapiens
Chains
3
Atoms
15,511
Mol. weight
238.82 kDa
Ligands
ZN
Released
14 Dec 2004

Explore 1U6G in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1U6G contains 115 α-helices and 21 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 38 helices, 12 β-strands

ElementResiduesLengthSheet
α-helix18-3114
α-helix39-5315
α-helix87-10519
α-helix114-13623
α-helix138-1425
α-helix158-17114
α-helix175-1773
α-helix179-19113
α-helix199-21012
α-helix225-2273
α-helix228-2325
α-helix233-25321
α-helix256-27520
α-helix280-2823
α-helix283-29412
α-helix299-31113
α-helix317-3259
α-helix333-35220
α-helix357-3604
α-helix362-38120
α-helix388-40316
α-helix406-4105
α-helix416-42914
α-helix439-45416
α-helix458-47417
α-helix481-49414
α-helix498-52528
β-strand533-53531
β-strand538-54032
α-helix541-5433
α-helix556-57217
β-strand576-58052
α-helix582-5843
β-strand586-59161
β-strand599-60351
α-helix604-6107
α-helix611-6144
β-strand618-62033
α-helix621-6277
α-helix632-64514
β-strand648-64923
α-helix657-6593
β-strand667-67043
β-strand680-68231
α-helix688-71831
β-strand723-72534
α-helix726-73712
α-helix745-75713
β-strand761-76444
β-strand767-77374
Chain B: 3 helices, 7 β-strands
ElementResiduesLengthSheet
β-strand22-2871
β-strand31-3552
α-helix54-585
α-helix601
β-strand70-7345
β-strand78-8035
α-helix81-877
β-strand9316
β-strand10016
β-strand103-10535
Chain C: 74 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix6-149
α-helix20-3314
α-helix45-5612
α-helix62-7615
α-helix81-9414
α-helix101-11616
α-helix127-14216
α-helix148-16417
α-helix173-1808
α-helix181-1855
α-helix189-20214
α-helix210-22011
α-helix230-24011
α-helix243-2453
α-helix252-2609
α-helix268-28013
α-helix287-29711
α-helix348-36114
α-helix368-3725
α-helix376-3805
α-helix389-40517
α-helix424-4318
α-helix434-4429
α-helix448-46417
α-helix470-4723
α-helix473-48311
α-helix491-50616
α-helix510-5134
α-helix514-5174
α-helix521-5288
α-helix533-55018
α-helix562-57615
α-helix583-59917
α-helix601-6033
α-helix607-61812
α-helix624-63512
α-helix645-65814
α-helix664-68017
α-helix687-6948
α-helix698-7003
α-helix706-71914
α-helix724-7296
α-helix735-7428
α-helix749-76315
α-helix772-7798
α-helix793-80917
α-helix815-8184
α-helix832-84817
α-helix856-8638
α-helix864-8663
α-helix870-88617
α-helix888-90013
α-helix903-9053
α-helix906-91813
α-helix926-93611
α-helix947-96014
α-helix963-9653
α-helix967-9704
α-helix979-98810
α-helix990-9923
α-helix1000-10078
α-helix1012-10154
α-helix1021-103616
α-helix1038-10403
α-helix1042-10443
α-helix1045-105410
α-helix1060-10623
β-strand1063-106867
β-strand1070-107677
α-helix1078-109417
α-helix1102-111110
α-helix1117-113216
α-helix1136-11394
α-helix1146-11549
α-helix1163-118220
α-helix1200-12089

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Cullin homolog 1Aprotein776Homo sapiensQ13616 (AlphaFold model)
RING-box protein 1Bprotein108Homo sapiensP62877 (AlphaFold model)
TIP120 proteinCprotein1230Homo sapiensQ86VP6 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>1U6G_1 Cullin homolog 1 (chains A)
MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSN
QARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYT
QQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVT
NAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADT
ERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHL
EIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAAL
NDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPE
LLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSA
SDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVL
SSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYT
LQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDE
VELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMK
MRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA
Sequence of entity 2 (B), FASTA
>1U6G_2 RING-box protein 1 (chains B)
MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQ
ASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH
Sequence of entity 3 (C), FASTA
>1U6G_3 TIP120 protein (chains C)
MASASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDK
NGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPA
SSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCL
LPQLTSPRLAVRKRTIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTYIQCIAA
ISRQAGHRIGEYLEKIIPLVVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVSTIINI
CLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQGSDDEYSDDDDMSWKVRRAAAKCLDAV
VSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWLCDPDAMEQ
GETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQHIPVLVPGI
IFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPFYKITSEAL
LVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVKERAISCMGQIICNL
GDNLGSDLPNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGVPILASFLR
KNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQMAISFLTTLA
KVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGYMDLLRMLT
GPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKNSRSTDSIRLLALL
SLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEYLPFVLQEIT
SQPKRQYLLLHSLKEIISSASVVGLKPYVENIWALLLKHCECAEEGTRNVVAECLGKLTL
IDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLEDPDL
NVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLD
IRKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLCPSAVLQ
RLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQS
QISSNPELAAIFESIQKDSSSTNLESMDTS

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn3

Primary citation

Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. Goldenberg, S.J., Cascio, T.C., Shumway, S.D. et al. Cell (2004) 119:517-528. DOI 10.1016/j.cell.2004.10.019 · PubMed

Other PDB entries of the same protein (UniProt Q13616 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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