1UZX: A complex of the Vps23 UEV with ubiquitin

A complex of the Vps23 UEV with ubiquitin. Determined by X-ray diffraction at 1.85 Å resolution. Released 30 Mar 2004.

Method: X-ray diffraction
Resolution: 1.85 Å
Organisms: SACCHAROMYCES CEREVISIAE, BOS TAURUS
Chains: 2
Atoms: 1,860
Mol. weight: 28.21 kDa
Released: 30 Mar 2004

Explore 1UZX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1UZX contains 10 α-helices and 13 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 6 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	11-24	14
α-helix	28-41	14
β-strand	45-53	9	1
β-strand	59-69	11	1
β-strand	81-86	6	1
β-strand	97-100	4	1
α-helix	115-119	5
β-strand	120	1	2
β-strand	126	1	2
α-helix	129-132	4
α-helix	141-149	9
α-helix	151-153	3

Chain B: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	3
β-strand	12-16	5	3
β-strand	22	1	4
α-helix	23-34	12
α-helix	38-40	3
β-strand	41-45	5	3
β-strand	48-49	2	3
α-helix	50-51	2
β-strand	55	1	4
α-helix	57-59	3
β-strand	66-71	6	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Vacuolar protein sorting-associated protein VPS23	A	protein	169	SACCHAROMYCES CEREVISIAE	P25604 (AlphaFold model)
Ubiquitin	B	protein	76	BOS TAURUS	P0CH28 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1UZX_1 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS23 (chains A)
MAHHHHHHMSANGKISVPEAVVNWLFKVIQPIYNDGRTTFHDSLALLDNFHSLRPRTRVF
THSDGTPQLLLSIYGTISTGEDGSSPHSIPVIMWVPSMYPVKPPFISINLENFDMNTISS
SLPIQEYIDSNGWIALPILHCWDPAAMNLIMVVQELMSLLHEPPQDQAP

Sequence of entity 2 (B), FASTA

>1UZX_2 UBIQUITIN (chains B)
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGG

Primary citation

Structural Insights Into Endosomal Sorting Complex Required for Transport (Escrt-I) Recognition of Ubiquitinated Proteins. Teo, H., Veprintsev, D., Williams, R.L. J Biol Chem (2004) 279:28689. DOI 10.1074/JBC.M400023200 · PubMed

Other PDB entries of the same protein (UniProt P25604 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3R3Q 1.45 Å, Crystal structure of the yeast Vps23 UEV domain
3R42 1.87 Å, Crystal structure of the yeast vps23 UEV domain in complex with a vps27 PSDP peptide
2F6M 2.1 Å, Structure of a Vps23-C:Vps28-N subcomplex
2P22 2.7 Å, Structure of the Yeast ESCRT-I Heterotetramer Core
2F66 2.8 Å, Structure of the ESCRT-I endosomal trafficking complex
2CAZ 3.6 Å, ESCRT-I core

Browse structure collections

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