1XJV: Human POT1

Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG). Determined by X-ray diffraction at 1.73 Å resolution. Released 14 Dec 2004.

Method: X-ray diffraction
Resolution: 1.73 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,766
Mol. weight: 36.31 kDa
Released: 14 Dec 2004

Explore 1XJV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1XJV contains 15 α-helices and 14 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 15 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	11-13	3
α-helix	14-16	3
β-strand	21-37	17	1
β-strand	43-50	8	1
β-strand	56-63	8	1
α-helix	66-68	3
β-strand	78-89	12	1
β-strand	92-106	15	1
β-strand	117	1	1
α-helix	127-143	17
α-helix	153-155	3
β-strand	161-173	13	2
β-strand	178-184	7	2
α-helix	192	1
β-strand	193	1	2
α-helix	194	1
α-helix	196-198	3
β-strand	204-205	2	2
α-helix	207-213	7
α-helix	214-216	3
β-strand	218-223	6	2
α-helix	226-232	7
α-helix	233-234	2
β-strand	238-251	14	2
β-strand	257-265	9	2
α-helix	270-272	3
β-strand	274-278	5	2
α-helix	279	1
α-helix	283-297	15

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
hT10 d(TTAGGGTTAG)	B	DNA	10
Protection of telomeres 1	A	protein	294	Homo sapiens	Q9NUX5 (AlphaFold model)

Sequence of entity 1 (B), FASTA

>1XJV_1 hT10 d(TTAGGGTTAG) (chains B)
TTAGGGTTAG

Sequence of entity 2 (A), FASTA

>1XJV_2 Protection of telomeres 1 (chains A)
ATNYIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGTDYCSVVTIVDQTNVKLTCLLFSGN
YEALPIIYKNGDIVRFHRLKIQVYKKETQGITSSGFASLTFEGTLGAPIIPRTSSKYFNF
TTEDHKMVEALRVWASTHMSPSWTLLKLCDVQPMQYFDLTCQLLGKAEVDGASFLLKVWD
GTRTPFPSWRVLIQDLVLEGDLSHIHRLQNLTIDILVYDNHVHVARSLKVGSFLRIYSLH
TKLQSMNSENQTMLSLEFHLHGGTSYGRGIRVLPESNSDVDQLKKDLESANLTA

Primary citation

Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Lei, M., Podell, E.R., Cech, T.R. Nat Struct Mol Biol (2004) 11:1223-1229. DOI 10.1038/nsmb867 · PubMed

Other PDB entries of the same protein (UniProt Q9NUX5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3KJO 1.8 Å, Crystal Structure of hPOT1V2-dTrUd(AGGGTTAG)
3KJP 1.8 Å, Crystal Structure of hPOT1V2-GGTTAGGGTTAG
5H65 2.1 Å, Crystal structure of human POT1 and TPP1
5UN7 2.1 Å, Structure of the human POT1-TPP1 telomeric complex
8SH0 2.16 Å, Structure of human POT1 DNA binding domain bound to a 5'-phosphorylated junction of a…
7S1O 2.55 Å, Structure of human POT1C
7S1U 2.55 Å, Structure of human POT1C
8SH1 2.6 Å, Structure of human POT1 DNA binding domain bound to a 5'-phosphorylated junction of a…
7S1T 2.9 Å, Structure of the human POT1-TPP1 complex
8SOJ 3.8 Å, Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the absence of telomeric ssDNA
7QXB 3.9 Å, Cryo-EM map of human telomerase-DNA-TPP1-POT1 complex (sharpened map)
7QXS 3.9 Å, Cryo-EM structure of human telomerase-DNA-TPP1-POT1 complex (with POT1 side chains)

Browse structure collections

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