1XKK: EGFR kinase domain

EGFR kinase domain complexed with a quinazoline inhibitor- GW572016. Determined by X-ray diffraction at 2.4 Å resolution. Released 7 Dec 2004.

Method: X-ray diffraction
Resolution: 2.4 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,376
Mol. weight: 41.1 kDa
Ligands: PO4, FMM
Released: 7 Dec 2004

Explore 1XKK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1XKK contains 18 α-helices and 12 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 18 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	705-706	2	1
β-strand	712-720	9	1
β-strand	724-731	8	1
β-strand	740-747	8	1
α-helix	756-768	13
β-strand	774	1	2
β-strand	777-782	6	1
β-strand	786-791	6	1
β-strand	797	1	2
α-helix	798-804	7
α-helix	811-830	20
α-helix	840-842	3
β-strand	843-847	5	2
β-strand	850-853	4	2
α-helix	858-861	4
α-helix	883-888	6
α-helix	893-908	16
α-helix	912-913	2
α-helix	920-922	3
α-helix	923-929	7
α-helix	933-936	4
β-strand	939	1	3
α-helix	941-950	10
α-helix	955-957	3
α-helix	959-960	2
α-helix	961-973	13
α-helix	975-978	4
β-strand	979	1	3
α-helix	996-1002	7
α-helix	1013-1016	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Epidermal growth factor receptor	A	protein	352	Homo sapiens	P00533 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1XKK_1 Epidermal growth factor receptor (chains A)
MKKGHHHHHHDYDIPTTENLYFQGSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGL
WIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIT
QLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTF
GSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSK
MARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQG

Ligands and cofactors

ID	Name	Formula	Copies
PO4	Phosphate ion	O4 P	2
FMM	N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amin…	C29 H26 Cl F N4 O4 S	1

Primary citation

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Wood, E.R., Truesdale, A.T., McDonald, O.B. et al. Cancer Res (2004) 64:6652-6659. DOI 10.1158/0008-5472.CAN-04-1168 · PubMed

Other PDB entries of the same protein (UniProt P00533 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8A27 1.07 Å, EGFR kinase domain in complex with 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[6-[2…
8A2D 1.11 Å, EGFR kinase domain (L858R/V948R) in complex with 2-[4-(difluoromethyl)-6-[2-[4-[[4-(hydro…
5UG9 1.33 Å, Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with a…
5HG8 1.42 Å, EGFR (L858R, T790M, V948R) in complex with N-[3-({2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-…
8A2A 1.43 Å, EGFR kinase domain in complex with 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[6-[2…
5UG8 1.46 Å, Crystal structure of the EGFR kinase domain (L858R, T790M, V948R) in complex with a…
3POZ 1.5 Å, EGFR Kinase domain complexed with tak-285
6TFV 1.5 Å, Crystal Structure of EGFR T790M/V948R in Complex with Covalent Pyrrolopyrimidine 18b
6TG0 1.5 Å, Crystal Structure of EGFR T790M/V948R in Complex with Covalent Pyrrolopyrimidine 21a
3VRP 1.52 Å, Crystal structure of the tyrosine kinase binding domain of Cbl-c in complex with…
5HG5 1.52 Å, EGFR (L858R, T790M, V948R) in complex with N-{3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]am…
5CNO 1.55 Å, Crystal structure of the EGFR kinase domain mutant V924R

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1XKK is part of these collections:

Kinases and cancer drug targets

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