28KE: Human holo-TFIIH-XPC-XPA complex
Cryo-EM structure of the human holo-TFIIH-XPC-XPA complex bound to bulky lesion-mimic DNA. Determined by electron microscopy at 3.6 Å resolution. Released 6 May 2026.
- Method
- Electron microscopy
- Resolution
- 3.6 Å
- Organisms
- Homo sapiens, synthetic construct
- Chains
- 12
- Atoms
- 24,107
- Mol. weight
- 595.87 kDa
- Ligands
- SF4, ZN
- Released
- 6 May 2026
Explore 28KE in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
28KE contains 146 α-helices and 119 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 32 helices, 32 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 59-60 | 2 | 1 |
| α-helix | 66 | 1 | |
| β-strand | 67 | 1 | 2 |
| α-helix | 68 | 1 | |
| β-strand | 78 | 1 | 3 |
| β-strand | 84-87 | 4 | 3 |
| α-helix | 93-103 | 11 | |
| β-strand | 105-108 | 4 | 3 |
| β-strand | 113-117 | 5 | 3 |
| α-helix | 120-128 | 9 | |
| α-helix | 133-143 | 11 | |
| β-strand | 146 | 1 | 2 |
| α-helix | 150-161 | 12 | |
| β-strand | 167-171 | 5 | 4 |
| β-strand | 174-178 | 5 | 4 |
| α-helix | 182-190 | 9 | |
| α-helix | 192-197 | 6 | |
| β-strand | 198 | 1 | 4 |
| β-strand | 206 | 1 | 5 |
| β-strand | 268 | 1 | 5 |
| β-strand | 271-272 | 2 | 4 |
| α-helix | 277-286 | 10 | |
| β-strand | 292 | 1 | 4 |
| β-strand | 294-295 | 2 | 6 |
| α-helix | 304-305 | 2 | |
| β-strand | 310 | 1 | 7 |
| α-helix | 318-325 | 8 | |
| β-strand | 333-334 | 2 | 6 |
| β-strand | 336-339 | 4 | 8 |
| α-helix | 347-357 | 11 | |
| β-strand | 361-364 | 4 | 8 |
| α-helix | 368-380 | 13 | |
| β-strand | 382 | 1 | 7 |
| β-strand | 390-391 | 2 | 8 |
| β-strand | 405-408 | 4 | 8 |
| α-helix | 410-413 | 4 | |
| α-helix | 421-431 | 11 | |
| β-strand | 435-441 | 7 | 8 |
| α-helix | 443-445 | 3 | |
| α-helix | 449-456 | 8 | |
| β-strand | 460-467 | 8 | 8 |
| α-helix | 477-479 | 3 | |
| α-helix | 480-483 | 4 | |
| β-strand | 487-490 | 4 | 8 |
| α-helix | 493-498 | 6 | |
| β-strand | 506-512 | 7 | 9 |
| α-helix | 513-515 | 3 | |
| α-helix | 516-524 | 9 | |
| α-helix | 530-535 | 6 | |
| α-helix | 538-552 | 15 | |
| β-strand | 558-561 | 4 | 9 |
| α-helix | 565-575 | 11 | |
| β-strand | 579-580 | 2 | 9 |
| α-helix | 586-598 | 13 | |
| β-strand | 604-607 | 4 | 9 |
| α-helix | 617-619 | 3 | |
| β-strand | 622-625 | 4 | 9 |
| α-helix | 633-640 | 8 | |
| β-strand | 658-664 | 7 | 9 |
| α-helix | 668-675 | 8 | |
| α-helix | 678-683 | 6 | |
| β-strand | 688-690 | 3 | 9 |
| α-helix | 708-718 | 11 | |
| α-helix | 775-779 | 5 | |
Chain B: 34 helices, 24 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-4 | 3 | 10 |
| β-strand | 9-11 | 3 | 10 |
| α-helix | 19-34 | 16 | |
| β-strand | 38-41 | 4 | 11 |
| α-helix | 47-62 | 16 | |
| β-strand | 70-74 | 5 | 11 |
| α-helix | 77-98 | 22 | |
| β-strand | 105-107 | 3 | 11 |
| α-helix | 127-137 | 11 | |
| α-helix | 140-146 | 7 | |
| α-helix | 156-164 | 9 | |
| α-helix | 169-171 | 3 | |
| β-strand | 173-174 | 2 | 11 |
| α-helix | 177-187 | 11 | |
| α-helix | 191-198 | 8 | |
| β-strand | 204-208 | 5 | 11 |
| α-helix | 210-213 | 4 | |
| α-helix | 221-223 | 3 | |
| β-strand | 230-233 | 4 | 11 |
| α-helix | 240-246 | 7 | |
| β-strand | 248-251 | 4 | 12 |
| α-helix | 253-276 | 24 | |
| α-helix | 279-288 | 10 | |
| α-helix | 321-323 | 3 | |
| α-helix | 326-343 | 18 | |
| β-strand | 350-352 | 3 | 12 |
| α-helix | 354-365 | 12 | |
| α-helix | 370-386 | 17 | |
| α-helix | 395-407 | 13 | |
| β-strand | 414-419 | 6 | 12 |
| β-strand | 432-437 | 6 | 12 |
| α-helix | 441-449 | 9 | |
| β-strand | 453-458 | 6 | 11 |
| α-helix | 466-470 | 5 | |
| β-strand | 477-478 | 2 | 11 |
| β-strand | 490-494 | 5 | 13 |
| β-strand | 495 | 1 | 14 |
| β-strand | 497 | 1 | 15 |
| β-strand | 503 | 1 | 15 |
| α-helix | 508-510 | 3 | |
| α-helix | 514-530 | 17 | |
| β-strand | 534-539 | 6 | 13 |
| α-helix | 542-554 | 13 | |
| α-helix | 557-562 | 6 | |
| β-strand | 566-569 | 4 | 13 |
| α-helix | 574-589 | 16 | |
| β-strand | 594-599 | 6 | 13 |
| α-helix | 604-607 | 4 | |
| β-strand | 617-620 | 4 | 13 |
| α-helix | 631-644 | 14 | |
| α-helix | 648-664 | 17 | |
| β-strand | 675-679 | 5 | 13 |
| α-helix | 682-685 | 4 | |
| α-helix | 687-691 | 5 | |
| α-helix | 695-698 | 4 | |
| α-helix | 703-705 | 3 | |
| β-strand | 708 | 1 | 14 |
| α-helix | 710-724 | 15 | |
Chain C: 7 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 399-412 | 14 | |
| α-helix | 424-434 | 11 | |
| α-helix | 455-477 | 23 | |
| α-helix | 484-500 | 17 | |
| α-helix | 501-505 | 5 | |
| α-helix | 506-515 | 10 | |
| α-helix | 523-547 | 25 | |
Chain D: 25 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-24 | 6 | |
| α-helix | 28-34 | 7 | |
| α-helix | 38-45 | 8 | |
| α-helix | 50-58 | 9 | |
| β-strand | 66-67 | 2 | 16 |
| α-helix | 68-72 | 5 | |
| β-strand | 75 | 1 | 17 |
| α-helix | 77-79 | 3 | |
| α-helix | 80-92 | 13 | |
| β-strand | 96-101 | 6 | 16 |
| β-strand | 105-110 | 6 | 16 |
| α-helix | 112-122 | 11 | |
| α-helix | 142-144 | 3 | |
| α-helix | 145-164 | 20 | |
| α-helix | 173-181 | 9 | |
| β-strand | 185-186 | 2 | 18 |
| β-strand | 195-196 | 2 | 18 |
| α-helix | 198-204 | 7 | |
| α-helix | 208-221 | 14 | |
| α-helix | 224-226 | 3 | |
| α-helix | 230-241 | 12 | |
| β-strand | 249-250 | 2 | 19 |
| α-helix | 256-268 | 13 | |
| β-strand | 271-272 | 2 | 20 |
| β-strand | 280-281 | 2 | 19 |
| β-strand | 282-283 | 2 | 20 |
| α-helix | 285-288 | 4 | |
| β-strand | 307-309 | 3 | 1 |
| β-strand | 314-317 | 4 | 1 |
| α-helix | 322-330 | 9 | |
| β-strand | 333-338 | 6 | 1 |
| β-strand | 341-345 | 5 | 1 |
| α-helix | 348-357 | 10 | |
| α-helix | 361-370 | 10 | |
| β-strand | 372 | 1 | 1 |
| α-helix | 374-378 | 5 | |
| α-helix | 385-396 | 12 | |
| α-helix | 397-399 | 3 | |
| β-strand | 402-406 | 5 | 21 |
| β-strand | 407-409 | 3 | 22 |
| α-helix | 415-428 | 14 | |
| β-strand | 431-433 | 3 | 22 |
| β-strand | 441-443 | 3 | 22 |
| α-helix | 447-461 | 15 | |
Chain E: 20 helices, 20 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-12 | 3 | |
| α-helix | 18-21 | 4 | |
| α-helix | 31-42 | 12 | |
| β-strand | 59-60 | 2 | 23 |
| β-strand | 63-66 | 4 | 24 |
| α-helix | 69-71 | 3 | |
| α-helix | 80-98 | 19 | |
| β-strand | 103 | 1 | 23 |
| β-strand | 104-110 | 7 | 24 |
| β-strand | 113-121 | 9 | 24 |
| α-helix | 124-133 | 10 | |
| α-helix | 145-156 | 12 | |
| β-strand | 164-165 | 2 | 23 |
| β-strand | 166-171 | 6 | 24 |
| α-helix | 182-192 | 11 | |
| β-strand | 195-200 | 6 | 24 |
| α-helix | 206-214 | 9 | |
| β-strand | 219-221 | 3 | 24 |
| α-helix | 225-234 | 10 | |
| α-helix | 238-241 | 4 | |
| β-strand | 249-253 | 5 | 25 |
| β-strand | 257-258 | 2 | 26 |
| α-helix | 273-275 | 3 | |
| α-helix | 281-283 | 3 | |
| β-strand | 289-290 | 2 | 27 |
| β-strand | 297-298 | 2 | 27 |
| β-strand | 303-304 | 2 | 25 |
| β-strand | 311-312 | 2 | 25 |
| α-helix | 315-318 | 4 | |
| α-helix | 319-321 | 3 | |
| α-helix | 327-329 | 3 | |
| β-strand | 332-335 | 4 | 28 |
| α-helix | 336-338 | 3 | |
| β-strand | 344 | 1 | 29 |
| β-strand | 351 | 1 | 29 |
| β-strand | 356-359 | 4 | 28 |
| β-strand | 366-367 | 2 | 28 |
| α-helix | 369-374 | 6 | |
| α-helix | 375-379 | 5 | |
| α-helix | 383-387 | 5 | |
Chain F: 12 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-16 | 10 | 30 |
| α-helix | 19-27 | 9 | |
| α-helix | 34-51 | 18 | |
| β-strand | 56-62 | 7 | 30 |
| β-strand | 67-69 | 3 | 30 |
| α-helix | 102-120 | 19 | |
| α-helix | 133-147 | 15 | |
| β-strand | 156-165 | 10 | 30 |
| α-helix | 168-169 | 2 | |
| α-helix | 174-186 | 13 | |
| β-strand | 190-195 | 6 | 30 |
| α-helix | 201-210 | 10 | |
| β-strand | 214-216 | 3 | 30 |
| α-helix | 224-226 | 3 | |
| α-helix | 227-231 | 5 | |
| α-helix | 235-238 | 4 | |
| β-strand | 241 | 1 | 17 |
| α-helix | 244-246 | 3 | |
| β-strand | 248-249 | 2 | 26 |
| β-strand | 253-254 | 2 | 31 |
| β-strand | 261-262 | 2 | 31 |
| β-strand | 264-268 | 5 | 25 |
| β-strand | 274-275 | 2 | 25 |
| α-helix | 283-288 | 6 | |
Chain G: 2 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4 | 1 | 32 |
| β-strand | 7-11 | 5 | 21 |
| α-helix | 14-25 | 12 | |
| β-strand | 34-37 | 4 | 21 |
| β-strand | 42-45 | 4 | 21 |
| α-helix | 51-63 | 13 | |
Chain H: 4 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 67-81 | 15 | |
| α-helix | 92-110 | 19 | |
| α-helix | 115-128 | 14 | |
| α-helix | 131-139 | 9 | |
2 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| General transcription and DNA repair factor IIH helicase subunit XPB | A | protein | 797 | Homo sapiens | P19447 (AlphaFold model) |
| TFIIH basal transcription factor complex helicase XPD subunit | B | protein | 771 | Homo sapiens | P18074 (AlphaFold model) |
| General transcription factor IIH subunit 1 | C | protein | 591 | Homo sapiens | P32780 (AlphaFold model) |
| General transcription factor IIH subunit 4 | D | protein | 462 | Homo sapiens | Q92759 (AlphaFold model) |
| General transcription factor IIH subunit 2 | E | protein | 395 | Homo sapiens | Q13888 |
| General transcription factor IIH subunit 3 | F | protein | 308 | Homo sapiens | Q13889 |
| General transcription factor IIH subunit 5 | G | protein | 71 | Homo sapiens | Q6ZYL4 |
| CDK-activating kinase assembly factor MAT1 | H | protein | 309 | Homo sapiens | P51948 |
| DNA repair protein complementing XP-C cells | I | protein | 940 | Homo sapiens | Q01831 |
| DNA repair protein complementing XP-A cells | N | protein | 273 | Homo sapiens | P23025 |
| DNA lesion strand | L | DNA | 48 | synthetic construct | |
| DNA non-lesion strand | M | DNA | 69 | synthetic construct | |
Sequence of entity 1 (A), FASTA
>28KE_1 General transcription and DNA repair factor IIH helicase subunit XPB (chains A)
HHHHHHENLYFQSNAMGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQ
VDESGTKVDEYGAKDYRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAE
PVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGK
VKLVLKHNRYFVESCHPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKSAISKTAE
SSGGPSTSRVTDPQGKSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCI
HLEYPLLAEYDFRNDSVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAG
KSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSV
AISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLG
LTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAI
KTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTS
QGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLR
AKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFST
KEEQQQLLQKVLAATDLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYMEYHSSR
SKAPSKHVHPLFKRFRK
Sequence of entity 2 (B), FASTA
>28KE_2 TFIIH basal transcription factor complex helicase XPD subunit (chains B)
MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQ
RAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPE
VTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDL
KALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARE
TDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSG
LAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMAT
FTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFT
SYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHA
AQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYF
LRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQLSSNDYKDDDDK
Sequence of entity 3 (C), FASTA
>28KE_3 General transcription factor IIH subunit 1 (chains C)
MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGK
AKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQE
DPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDG
CNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSK
DLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSN
AAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEY
EDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQ
VLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRHFWSCFP
VNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQ
SRRLMKKTGSGGENLYFQSGSWSHPQFEKGGGSGGGSGGGSWSHPQFEKSG
Sequence of entity 4 (D), FASTA
>28KE_4 General transcription factor IIH subunit 4 (chains D)
MESTPSRGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRML
FLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRI
ALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLS
QAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQL
SFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGT
VHQPGFIVVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGIT
AQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFEL
LLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSS
Sequence of entity 5 (E), FASTA
>28KE_5 General transcription factor IIH subunit 2 (chains E)
MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRH
LYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTEL
SGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPS
NIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHVSPPP
ASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCE
LPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVC
AVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV
Sequence of entity 6 (F), FASTA
>28KE_6 General transcription factor IIH subunit 3 (chains F)
MVSDEDELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKLAVI
ASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMT
KSDIKGQHTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNV
IFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQ
LILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAK
KKKLKVSA
Sequence of entity 7 (G), FASTA
>28KE_7 General transcription factor IIH subunit 5 (chains G)
MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAELVNVLQERVGEL
MDQNAFSLTQK
Sequence of entity 8 (H), FASTA
>28KE_8 CDK-activating kinase assembly factor MAT1 (chains H)
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV
QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK
KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK
QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK
LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA
FSGLFWQPS
Sequence of entity 9 (I), FASTA
>28KE_9 DNA repair protein complementing XP-C cells (chains I)
MARKRAAGGEPRGRELRSQKSKAKSKARREEEEEDAFEDEKPPKKSLLSKVSQGKRKRGC
SHPGGSADGPAKKKVAKVTVKSENLKVIKDEALSDGDDLRDFPSDLKKAHHLKRGATMNE
DSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVKPVEIEIETPEQAKTRERSE
KIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPAR
FTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIYSARDDEELVH
IFLLILRALQLLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKP
KTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSEEDEGPGDKQEKATQRRPHGR
ERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKAPAPQRTKAGS
KSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEE
KWVCVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDA
EWWAETLRPYQSPFMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIY
PETAAILGYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLA
EPQLREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLH
RVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKK
EKRALGNWKLLAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARIL
AASWPQNREDEEKQKLKGGPKKTKREKKAAASHLFPFEQL
Sequence of entity 10 (N), FASTA
>28KE_10 DNA repair protein complementing XP-A cells (chains N)
MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMA
NVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNH
FDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKL
YLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRETI
VHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM
Sequence of entity 11 (L), FASTA
>28KE_11 DNA lesion strand (chains L)
CCCATTCCAACCATCCCACTACCXTCCATCTTCACTCAACTATCACCC
Sequence of entity 12 (M), FASTA
>28KE_12 DNA non-lesion strand (chains M)
AGAGAAGGAGAGGCAAGGAAGGGTGATAGTTGAGTGAAGATGGACAGGTAGTGGGATGGT
TGGAATGGG
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| SF4 | Iron/sulfur cluster | Fe4 S4 | 1 |
| ZN | Zinc ion | Zn | 6 |
Primary citation
Visualization of stepwise derepression of TFIIH in global genome nucleotide excision repair. de Martin Garrido, N., Haste, C.A.F., Feng, J. et al. Sci Adv (2026) 12:eaeb3506-eaeb3506. DOI 10.1126/sciadv.aeb3506 · PubMed
Other PDB entries of the same protein (UniProt P19447 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4ERN 1.8 Å, Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair protein…
- 7NVV 2.9 Å, XPB-containing part of TFIIH in a post-translocated state (with ADP-BeF3)
- 28JM 3.29 Å, Cryo-EM structure of the human holo-TFIIH and XPC initial encounter complex
- 7EGB 3.3 Å, TFIID-based holo PIC on SCP promoter
- 8EBU 3.3 Å, XPC release from Core7-XPA-DNA (Cy5)
- 9PD3 3.3 Å, NER dual incision complex - DuIS
- 28JS 3.32 Å, Cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA…
- 9PD4 3.4 Å, NER dual incision complex - DuIM
- 6RO4 3.5 Å, Structure of the core TFIIH-XPA-DNA complex
- 7AD8 3.5 Å, Core TFIIH-XPA-DNA complex with modelled p62 subunit
- 9XYU 3.5 Å, NER complex - C7CAD.ATP
- 8EBX 3.6 Å, XPA repositioning Core7 of TFIIH relative to XPC-DNA lesion (AP)
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