29IX: Large ribosomal subunit protein uL30
Human monosomes with bound toxin NT-2, focus on 60S subunit. NT-2 added to purified ribosomes as control. Determined by electron microscopy at 2.2 Å resolution. Released 30 Sept 2026.
- Method
- Electron microscopy
- Resolution
- 2.2 Å
- Organism
- Homo sapiens
- Chains
- 44
- Atoms
- 142,776
- Mol. weight
- 2564.25 kDa
- Ligands
- MG, ZN, PUT, SPD
- Released
- 30 Sept 2026
Explore 29IX in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
29IX contains 350 α-helices and 301 β-strands across 41 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain Aa: 8 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 16-18 | 3 | |
| β-strand | 20-24 | 5 | 5 |
| β-strand | 30-34 | 5 | 5 |
| α-helix | 35-39 | 5 | |
| α-helix | 41-42 | 2 | |
| β-strand | 43 | 1 | 6 |
| α-helix | 44 | 1 | |
| β-strand | 52 | 1 | 6 |
| α-helix | 53 | 1 | |
| α-helix | 61-66 | 6 | |
| α-helix | 69-72 | 4 | |
| α-helix | 84-106 | 23 | |
Chain AA: 14 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 27-78 | 52 | |
| β-strand | 81-83 | 3 | 1 |
| α-helix | 84-87 | 4 | |
| β-strand | 89-94 | 6 | 2 |
| α-helix | 103-112 | 10 | |
| β-strand | 119-124 | 6 | 2 |
| α-helix | 127-135 | 9 | |
| α-helix | 137-139 | 3 | |
| β-strand | 140-143 | 4 | 2 |
| α-helix | 147-157 | 11 | |
| β-strand | 159-162 | 4 | 3 |
| β-strand | 165-168 | 4 | 3 |
| α-helix | 172-179 | 8 | |
| α-helix | 180-182 | 3 | |
| α-helix | 187-196 | 10 | |
| α-helix | 201-207 | 7 | |
| β-strand | 208 | 1 | 3 |
| α-helix | 209-210 | 2 | |
| β-strand | 211-212 | 2 | 2 |
| α-helix | 213-215 | 3 | |
| β-strand | 226 | 1 | 4 |
| α-helix | 227-229 | 3 | |
| β-strand | 233 | 1 | 4 |
| β-strand | 234-237 | 4 | 2 |
| α-helix | 240-247 | 8 | |
Chain Ab: 7 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-10 | 5 | |
| α-helix | 14-36 | 23 | |
| α-helix | 41-73 | 33 | |
| α-helix | 89-92 | 4 | |
| α-helix | 97-101 | 5 | |
| α-helix | 105-113 | 9 | |
| α-helix | 115-118 | 4 | |
| β-strand | 119-121 | 3 | 29 |
Chain AB: 18 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 45-47 | 3 | |
| α-helix | 52-54 | 3 | |
| β-strand | 56 | 1 | 7 |
| α-helix | 59-73 | 15 | |
| β-strand | 75-76 | 2 | 8 |
| α-helix | 78-81 | 4 | |
| α-helix | 82-84 | 3 | |
| α-helix | 86-88 | 3 | |
| α-helix | 89-100 | 12 | |
| α-helix | 103-106 | 4 | |
| α-helix | 107-116 | 10 | |
| α-helix | 132-134 | 3 | |
| β-strand | 137-138 | 2 | 9 |
| α-helix | 140-148 | 9 | |
| β-strand | 154-158 | 5 | 9 |
| α-helix | 165-168 | 4 | |
| α-helix | 170-176 | 7 | |
| β-strand | 181-184 | 4 | 9 |
| α-helix | 187-193 | 7 | |
| β-strand | 201-204 | 4 | 9 |
| α-helix | 212-222 | 11 | |
| α-helix | 223-227 | 5 | |
| α-helix | 230-233 | 4 | |
| β-strand | 238-239 | 2 | 8 |
| α-helix | 244-253 | 10 | |
Chain Ac: 9 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7 | 1 | 14 |
| β-strand | 13 | 1 | 14 |
| α-helix | 18 | 1 | |
| β-strand | 19 | 1 | 28 |
| α-helix | 20-21 | 2 | |
| α-helix | 23-25 | 3 | |
| α-helix | 26-29 | 4 | |
| α-helix | 32-34 | 3 | |
| α-helix | 35-48 | 14 | |
| α-helix | 52-63 | 12 | |
| α-helix | 66-77 | 12 | |
| α-helix | 80-101 | 22 | |
Chain AC: 4 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-12 | 10 | 10 |
| β-strand | 17-21 | 5 | 11 |
| β-strand | 24-29 | 6 | 11 |
| β-strand | 32-37 | 6 | 11 |
| β-strand | 44-48 | 5 | 10 |
| β-strand | 53-62 | 10 | 10 |
| α-helix | 64-85 | 22 | |
| β-strand | 88-95 | 8 | 12 |
| β-strand | 102-106 | 5 | 13 |
| β-strand | 111-115 | 5 | 13 |
| α-helix | 117-119 | 3 | |
| β-strand | 124-127 | 4 | 13 |
| α-helix | 128-129 | 2 | |
| β-strand | 133-136 | 4 | 12 |
| β-strand | 143-148 | 6 | 12 |
| α-helix | 151-164 | 14 | |
| β-strand | 178-185 | 8 | 12 |
Chain Ad: 5 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-10 | 4 | |
| β-strand | 16-17 | 2 | 19 |
| β-strand | 27-28 | 2 | 19 |
| β-strand | 33-34 | 2 | 19 |
| α-helix | 44-45 | 2 | |
| α-helix | 51-57 | 7 | |
| α-helix | 67-74 | 8 | |
| α-helix | 84-86 | 3 | |
Chain AD: 10 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-5 | 3 | |
| α-helix | 6-9 | 4 | |
| α-helix | 15-16 | 2 | |
| α-helix | 26-29 | 4 | |
| β-strand | 35-37 | 3 | 15 |
| β-strand | 48-54 | 7 | 15 |
| β-strand | 58-61 | 4 | 16 |
| α-helix | 62-80 | 19 | |
| β-strand | 85-89 | 5 | 15 |
| β-strand | 95-99 | 5 | 16 |
| α-helix | 119-120 | 2 | |
| β-strand | 121-129 | 9 | 16 |
| β-strand | 134-140 | 7 | 15 |
| α-helix | 142-144 | 3 | |
| α-helix | 145-156 | 12 | |
| β-strand | 163-167 | 5 | 15 |
| β-strand | 170 | 1 | 17 |
| β-strand | 177 | 1 | 17 |
| α-helix | 178-186 | 9 | |
| β-strand | 190-193 | 4 | 18 |
| β-strand | 196-199 | 4 | 18 |
| α-helix | 206-211 | 6 | |
33 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Large ribosomal subunit protein uL30 | AA | protein | 248 | Homo sapiens | P18124 (AlphaFold model) |
| 60S ribosomal protein L7a | AB | protein | 266 | Homo sapiens | P62424 (AlphaFold model) |
| 60S ribosomal protein L9 | AC | protein | 192 | Homo sapiens | P32969 (AlphaFold model) |
| Ribosomal protein uL16-like | AD | protein | 214 | Homo sapiens | Q96L21 (AlphaFold model) |
| 60S ribosomal protein L11 | AE | protein | 178 | Homo sapiens | P62913 |
| 60S ribosomal protein L13 | AF | protein | 211 | Homo sapiens | P26373 |
| 60S ribosomal protein L14 | AG | protein | 215 | Homo sapiens | P50914 |
| 60S ribosomal protein L15 | AH | protein | 204 | Homo sapiens | P61313 |
| 60S ribosomal protein L13a | AI | protein | 203 | Homo sapiens | P40429 |
| 60S ribosomal protein L17 | AJ | protein | 184 | Homo sapiens | P18621 |
| 60S ribosomal protein L18 | AK | protein | 188 | Homo sapiens | Q07020 |
| 60S ribosomal protein L19 | AL | protein | 196 | Homo sapiens | P84098 |
32 more molecules are not listed.
Sequence of entity 1 (AA), FASTA
>29IX_1 Large ribosomal subunit protein uL30 (chains AA)
MEGVEEKKKEVPAVPETLKKKRRNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKE
YRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNG
TFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLG
KYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQI
NRLIRRMN
Sequence of entity 2 (AB), FASTA
>29IX_2 60S ribosomal protein L7a (chains AB)
MPKGKKAKGKKVAPAPAVVKKQEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRY
IRLQRQRAILYKRLKVPPAINQFTQALDRQTATQLLKLAHKYRPETKQEKKQRLLARAEK
KAAGKGDVPTKRPPVLRAGVNTVTTLVENKKAQLVVIAHDVDPIELVVFLPALCRKMGVP
YCIIKGKARLGRLVHRKTCTTVAFTQVNSEDKGALAKLVEAIRTNYNDRYDEIRRHWGGN
VLGPKSVARIAKLEKAKAKELATKLG
Sequence of entity 3 (AC), FASTA
>29IX_3 60S ribosomal protein L9 (chains AC)
MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKW
WGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGE
KYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIY
VSEKGTVQQADE
Sequence of entity 4 (AD), FASTA
>29IX_4 Ribosomal protein uL16-like (chains AD)
MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGGHMVSDEYEQL
SSEALEAARICANKYMVKSCGRDGFHMRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFG
KPQGTVARVHIGQVIMSIRTKLQNEEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADE
FEDMVAKKCLIPDGCGVKYVPSHGPLDKWRVLHS
Sequence of entity 5 (AE), FASTA
>29IX_5 60S ribosomal protein L11 (chains AE)
MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSF
GIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYD
PSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK
Sequence of entity 6 (AF), FASTA
>29IX_6 60S ribosomal protein L13 (chains AF)
MAPSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPIRPIVR
CPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLKEY
RSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPVRNVYKKEKARVITEEEKNFKAFA
SLRMARANARLFGIRAKRAKEAAEQDVEKKK
Sequence of entity 7 (AG), FASTA
>29IX_7 60S ribosomal protein L14 (chains AG)
MVFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMPFKCMQLTDF
ILKFPHSAHQKYVRQAWQKADINTKWAATRWAKKIEARERKAKMTDFDRFKVMKAKKMRN
RIIKNEVKKLQKAALLKASPKKAPGTKGTAAAAAAAAAAKVPAKKITAASKKAPAQKVPA
QKATGQKAAPAPKAQKGQKAPAQKAPAPKASGKKA
Sequence of entity 8 (AH), FASTA
>29IX_8 60S ribosomal protein L15 (chains AH)
MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYV
IYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSVAEERAGRHCGALRVLNSYW
VGEDSTYKFFEVILIDPFHKAIRRNPDTQWITKPVHKHREMRGLTSAGRKSRGLGKGHKF
HHTIGGSRRAAWRRRNTLQLHRYR
Sequence of entity 9 (AI), FASTA
>29IX_9 60S ribosomal protein L13a (chains AI)
MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRK
RMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVV
PAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLMRLRKQ
AEKNVEKKIDKYTEVLKTHGLLV
Sequence of entity 10 (AJ), FASTA
>29IX_10 60S ribosomal protein L17 (chains AJ)
MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPF
RRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVN
KAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKL
MARE
Sequence of entity 11 (AK), FASTA
>29IX_11 60S ribosomal protein L18 (chains AK)
MGVDIRHNKDRKVRRKEPKSQDIYLRLLVKLYRFLARRTNSTFNQVVLKRLFMSRTNRPP
LSLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPKLKVCALRVTSRARSRILRAGGKI
LTFDQLALDSPKGCGTVLLSGPRKGREVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGR
RASRGYKN
Sequence of entity 12 (AL), FASTA
>29IX_12 60S ribosomal protein L19 (chains AL)
MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSR
ARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMY
HSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAK
KEEIIKTLSKEEETKK
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 184 |
| ZN | Zinc ion | Zn | 5 |
| PUT | 1,4-diaminobutane | C4 H12 N2 | 4 |
| SPD | Spermidine | C7 H19 N3 | 4 |
| SPM | Spermine | C10 H26 N4 | 4 |
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 1 |
| A1JQ4 | Toxin NT-2 | C17 H24 O7 | 1 |
Water and common crystallization additives (K) are not listed.
Primary citation
Toxin NT-2 bound to human ribosome. Rabl, J., Karousis, E.D. To be published.
Other PDB entries of the same protein (UniProt P18124 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8A3D 1.67 Å, Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound
- 8GLP 1.67 Å, mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus…
- 29IW 1.77 Å, Human monosomes with bound toxin NT-2, focus on 60S subunit. Cells treated with NT-2.
- 8QYX 1.78 Å, Human 60S ribosomal subunit
- 8QOI 1.9 Å, Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical…
- 9O3W 1.9 Å, Human 80S ribosome bound to IDB-001 stalled on MYC nascent chain
- 8YOO 2.0 Å, Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline
- 9C3H 2.0 Å, Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site.
- 29IZ 2.08 Å, Dormant 80S:eEF2:SERBP1:tRNA complex from human cells treated with toxin NT-2
- 9TV2 2.1 Å, 80S ribosomes from primary B-cells infected with delta v-snoRNA1 EBV
- 9I2D 2.19 Å, NMT1-NAC bound human RNC with 10 amino acid ARF1-linker
- 9PBE 2.19 Å, In situ human 80S ribosome (composite map)
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