2ATP: CD8ab heterodimer

Crystal structure of a CD8ab heterodimer. Determined by X-ray diffraction at 2.4 Å resolution. Released 27 Dec 2005.

Method: X-ray diffraction
Resolution: 2.4 Å
Organism: Mus musculus
Chains: 6
Atoms: 3,836
Mol. weight: 60.48 kDa
Ligands: NAG
Released: 27 Dec 2005

Explore 2ATP in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2ATP contains 9 α-helices and 44 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	7-10	4	1
β-strand	14-16	3	2
α-helix	17	1
β-strand	22-28	7	1
β-strand	35-42	8	2
β-strand	51-57	7	2
β-strand	63-65	3	2
α-helix	66	1
β-strand	76-80	5	1
β-strand	84-89	6	1
β-strand	98-106	9	2
β-strand	109-112	4	2
β-strand	114	1	3
β-strand	116-120	5	2

Chain B: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	2-4	3	4
β-strand	7-10	4	3
β-strand	16-21	6	4
β-strand	30-38	9	3
β-strand	43-52	10	3
β-strand	56-59	4	3
α-helix	61-63	3
β-strand	69-72	4	4
β-strand	80-83	4	4
α-helix	88-90	3
β-strand	92-99	8	3
β-strand	104-106	3	3
β-strand	110-114	5	3

Chain C: 3 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	6-10	5	5
β-strand	22-29	8	5
β-strand	36-42	7	6
β-strand	51-56	6	6
β-strand	63-65	3	6
α-helix	67-69	3
β-strand	75-80	6	5
β-strand	84-89	6	5
α-helix	94-96	3
β-strand	98-106	9	6
β-strand	109-112	4	6
α-helix	113-115	3
β-strand	116-118	3	6

Chain D: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	2-4	3	7
β-strand	7-10	4	8
β-strand	16-21	6	7
β-strand	31-40	10	8
β-strand	42-52	11	8
β-strand	56-59	4	8
α-helix	66-68	3
β-strand	69-72	4	7
β-strand	80-83	4	7
α-helix	88-90	3
β-strand	92-99	8	8
β-strand	104-106	3	8
β-strand	110-114	5	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
T-cell surface glycoprotein CD8 alpha chain	A, C	protein	122	Mus musculus	P01731 (AlphaFold model)
artifact linker	E, F	protein	29
T-cell surface glycoprotein CD8 beta chain	B, D	protein	115	Mus musculus	P10300 (AlphaFold model)

Sequence of entity 1 (A, C), FASTA

>2ATP_1 T-cell surface glycoprotein CD8 alpha chain (chains A, C)
KPQAPELRIFPKKMDAELGQKVDLVCEVLGSVSQGCSWLFQNSSSKLPQPTFVVYMASSH
NKITWDEKLNSSKLFSAMRDTNNKYVLTLNKFSKENEGYYFCSVISNSVMYFSSVVPVLQ
KV

Sequence of entity 2 (E, F), FASTA

>2ATP_2 artifact linker (chains E, F)
AGSADDARKDAARKDDARKDDARKDGSSA

Sequence of entity 3 (B, D), FASTA

>2ATP_3 T-cell surface glycoprotein CD8 beta chain (chains B, D)
LIQTPSSLLVQTNHTAKMSCEVKSISKLTSIYWLRERQDPKDKYFEFLASWSSSKGVLYG
ESVDKKRNIILESSDSRRPFLSIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTVV

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	3

Primary citation

Structural and Mutational Analyses of a CD8alphabeta Heterodimer and Comparison with the CD8alphaalpha Homodimer. Chang, H.C., Tan, K., Ouyang, J. et al. Immunity (2005) 23:661-671. DOI 10.1016/j.immuni.2005.11.002 · PubMed

Other PDB entries of the same protein (UniProt P01731 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1NEZ 2.1 Å, The Crystal Structure of a TL/CD8aa Complex at 2.1A resolution:Implications for Memory T…
3DMM 2.6 Å, Crystal structure of the CD8 alpha beta/H-2Dd complex
3B9K 2.7 Å, Crystal structure of CD8alpha-beta in complex with YTS 156.7 FAB
1BQH 2.8 Å, Murine CD8AA ectodomain fragment in complex with H-2KB/VSV8
2ARJ 2.88 Å, CD8alpha-alpha in complex with YTS 105.18 Fab

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