2BEG: Alzheimer's Abeta(1-42) fibrils
3D Structure of Alzheimer's Abeta(1-42) fibrils. Determined by solution NMR. Released 22 Nov 2005.
- Method
- Solution NMR
- Organism
- Homo sapiens
- Chains
- 5
- Atoms
- 900
- Mol. weight
- 22.6 kDa
- Released
- 22 Nov 2005
Explore 2BEG in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
2BEG contains 0 α-helices and 10 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains A, B, C, D and E: 0 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 18-26 | 9 | 1 |
| β-strand | 31-41 | 11 | 2 |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Amyloid beta A4 protein | A, B, C, D, E | protein | 42 | Homo sapiens | P05067 (AlphaFold model) |
Sequence of entity 1 (A, B, C, D, E), FASTA
>2BEG_1 Amyloid beta A4 protein (chains A, B, C, D, E)
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Primary citation
3D structure of Alzheimer's amyloid-{beta}(1-42) fibrils. Luhrs, T., Ritter, C., Adrian, M. et al. Proc Natl Acad Sci U S A (2005) 102:17342-17347. DOI 10.1073/pnas.0506723102 · PubMed
Other PDB entries of the same protein (UniProt P05067 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 2FMA 0.85 Å, Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in…
- 6NB9 1.05 Å, Amyloid-Beta (20-34) with L-isoaspartate 23
- 6OIZ 1.1 Å, Amyloid-Beta (20-34) wild type
- 8T82 1.1 Å, Racemic mixture of amyloid beta segment 35-MVGGVV-40 forms heterochiral rippled…
- 5ONQ 1.17 Å, Alzheimer's Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd-substituted Thermolysin
- 3JQL 1.2 Å, Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide…
- 3PZZ 1.29 Å, Structure of an amyloid forming peptide GAIIGL (29-34) from amyloid beta
- 4PQD 1.33 Å, The longer crystal structure of the grow factor like domain from Beta amypoid precusor…
- 5ONP 1.34 Å, Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Cd-substituted Thermolysin
- 5ONR 1.39 Å, Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Thermolysin
- 4PWQ 1.4 Å, High-resolution crystal structure of the E1-domain of the amyloid precursor protein
- 7OW1 1.4 Å, Crystal Structure of TAP01 in complex with amyloid beta peptide
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