Crystal structure of human Cleavage and Polyadenylation Specificity Factor 5 (CPSF5). Determined by X-ray diffraction at 1.9 Å resolution. Released 4 May 2006.
Explore 2CL3 in 3D Show helices and sheets RCSB PDB PDBe
2CL3 contains 9 α-helices and 14 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 24-27 | 4 | |
| β-strand | 36-39 | 4 | 1 |
| β-strand | 41 | 1 | 2 |
| α-helix | 42-44 | 3 | |
| β-strand | 45-50 | 6 | 3 |
| α-helix | 60-74 | 15 | |
| β-strand | 77-84 | 8 | 4 |
| β-strand | 85-88 | 4 | 2 |
| β-strand | 91-100 | 10 | 2 |
| β-strand | 103-105 | 3 | 2 |
| β-strand | 108-110 | 3 | 4 |
| α-helix | 111-112 | 2 | |
| α-helix | 117-129 | 13 | |
| β-strand | 140-150 | 11 | 4 |
| β-strand | 158 | 1 | 4 |
| β-strand | 170-178 | 9 | 4 |
| α-helix | 179-180 | 2 | |
| β-strand | 183-188 | 6 | 3 |
| β-strand | 192-197 | 6 | 2 |
| α-helix | 198-201 | 4 | |
| α-helix | 205-212 | 8 | |
| α-helix | 215-219 | 5 | |
| β-strand | 223-226 | 4 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Cleavage and polyadenylation specificity factor 5 | A | protein | 230 | HOMO SAPIENS | O43809 (AlphaFold model) |
>2CL3_1 CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 5 (chains A) MHHHHHHSSGVDLGTENLYFQSMGNKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKD SSVAARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDE VEGLKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLV QLQEKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN
The Crystal Structure of Human Cleavage and Polyadenylation Specific Factor-5 Reveals a Dimeric Nudix Protein with a Conserved Catalytic Site. Tresaugues, L., Stenmark, P., Schuler, H. et al. Proteins (2008) 73:1047. DOI 10.1002/PROT.22198 · PubMed
Other PDB entries of the same protein (UniProt O43809 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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