2FY8: Calcium-gated potassium channel mthK

Crystal structure of MthK rck domain in its ligand-free gating-ring form. Determined by X-ray diffraction at 2.79 Å resolution. Released 5 Sept 2006.

Method

X-ray diffraction

Resolution

2.79 Å

Organism

Methanothermobacter thermautotrophicus

Chains

8

Atoms

13,851

Mol. weight

203.58 kDa

Released

5 Sept 2006

Explore 2FY8 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2FY8 contains 110 α-helices and 96 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 12 β-strands

Molecules and chains

>2FY8_1 Calcium-gated potassium channel mthK (chains A, B, C, D, E, F, G, H)
MGLIDVAKSRHVVICGWSESTLECLRELRGSEVFVLAEDENVRKKVLRSGANFVHGDPTR
VSDLEKANVRGARAVIVNLESDSETIHCILGIRKIDESVRIIAEAERYENIEQLRMAGAD
QVISPFVISGRLMSRSIDDGYEAMFVQDVLAEESTRRMVEVPIPEGSKLEGVSVLDADIH
DVTGVIIIGVGRGDELIIDPPRDYSFRAGDIILGIGKPEEIERLKNYISA

Primary citation

Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K(+) Channels. Ye, S., Li, Y., Chen, L. et al. Cell (2006) 126:1161-1173. DOI 10.1016/j.cell.2006.08.029 · PubMed

Related structures

Other PDB entries of the same protein (UniProt O27564 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 3LDC 1.45 Å, High resolution open MthK pore structure crystallized in 100 mM K+
• 3LDD 1.45 Å, High resolution open MthK pore structure crystallized in 100 mM K+ and further soaked in…
• 6U9T 1.55 Å, Wild-type MthK pore in 50 mM K+
• 4HYO 1.65 Å, Crystal Structure of MthK Pore
• 6U9P 1.65 Å, Wild-type MthK pore in ~150 mM K+
• 2AEF 1.7 Å, Crystal Structures of the MthK RCK Domain in Ca2+ bound form
• 4HZ3 1.7 Å, MthK pore crystallized in presence of TBSb
• 3OUS 1.75 Å, MthK channel pore T59A mutant
• 3R65 1.8 Å, MthK channel pore E92Q mutant
• 6U9Y 1.8 Å, Wild-type MthK pore in 11 mM K+
• 4L74 1.84 Å, Ca2+-bound MthK RCK domain at 1.9 Angstrom with single ligand
• 6U9Z 1.95 Å, Wild-type MthK pore in 6 mM K+

Browse structure collections

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