2I0I: Sap97 PDZ3

X-ray crystal structure of Sap97 PDZ3 bound to the C-terminal peptide of HPV18 E6. Determined by X-ray diffraction at 2.8 Å resolution. Released 20 Feb 2007.

Method: X-ray diffraction
Resolution: 2.8 Å
Organism: Rattus norvegicus
Chains: 6
Atoms: 1,981
Mol. weight: 29.17 kDa
Released: 20 Feb 2007

Explore 2I0I in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2I0I contains 7 α-helices and 30 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	465-469	5	1
β-strand	471	1	2
β-strand	474	1	2
β-strand	477-481	5	3
β-strand	488-493	6	3
α-helix	498-502	5
β-strand	510-511	2	3
β-strand	513-514	2	1
β-strand	517-518	2	1
α-helix	524-532	9
β-strand	537-541	5	1

Chain B: 3 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	465-469	5	4
β-strand	471	1	5
β-strand	474	1	5
β-strand	477-481	5	6
β-strand	488-493	6	6
α-helix	498-502	5
α-helix	509	1
β-strand	510-511	2	6
β-strand	513-514	2	4
β-strand	517-518	2	4
α-helix	524-532	9
β-strand	537-541	5	4

Chain C: 2 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	465-469	5	7
β-strand	471	1	8
β-strand	474	1	8
β-strand	477-481	5	9
β-strand	488-493	6	9
α-helix	498-502	5
β-strand	510	1	9
β-strand	513-514	2	7
β-strand	518	1	7
α-helix	524-532	9
β-strand	537-541	5	7

Chains D and E: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	2003-2005	3	3

Chain F: 0 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	2004-2005	2	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Disks large homolog 1	A, B, C	protein	85	Rattus norvegicus	Q62696 (AlphaFold model)
peptide E6	D, E, F	protein	7		P06463 (AlphaFold model)

Sequence of entity 1 (A, B, C), FASTA

>2I0I_1 Disks large homolog 1 (chains A, B, C)
ITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVD
LRAASHEQAAAALKNAGQAVTIVAQ

Sequence of entity 2 (D, E, F), FASTA

>2I0I_2 peptide E6 (chains D, E, F)
RRRETQV

Primary citation

Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein. Zhang, Y., Dasgupta, J., Ma, R.Z. et al. J Virol (2007) 81:3618-3626. DOI 10.1128/JVI.02044-06 · PubMed

Other PDB entries of the same protein (UniProt Q62696 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2AWX 1.8 Å, Synapse associated protein 97 PDZ2 domain variant C378S
2AWW 2.21 Å, Synapse associated protein 97 PDZ2 domain variant C378G with C-terminal GluR-A peptide
2I0L 2.31 Å, X-ray crystal structure of Sap97 PDZ2 bound to the C-terminal peptide of HPV18 E6.
2G2L 2.35 Å, Crystal Structure of the Second PDZ Domain of SAP97 in Complex with a GluR-A C-terminal…
2AWU 2.44 Å, Synapse associated protein 97 PDZ2 domain variant C378G
3UAT 2.7 Å, Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific…
1RSO Hetero-tetrameric L27 (Lin-2, Lin-7) domain complexes as organization platforms of…
1ZOK PDZ1 Domain Of Synapse Associated Protein 97

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