2IL6: Human interleukin-6, NMR, 32 structures

Human interleukin-6, NMR, 32 structures. Determined by solution NMR. Released 4 Feb 1998.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 1,331
Mol. weight: 21.01 kDa
Released: 4 Feb 1998

Explore 2IL6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2IL6 contains 7 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 0 β-strands

Element	Residues	Length
α-helix	22-46	25
α-helix	82-102	21
α-helix	110-130	21
α-helix	143-152	10
α-helix	157-170	14
α-helix	171-175	5
α-helix	176-184	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Interleukin-6	A	protein	185	Homo sapiens	P05231 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2IL6_1 INTERLEUKIN-6 (chains A)
APVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAE
NNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMST
KVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLR
ALRQM

Primary citation

Solution structure of recombinant human interleukin-6. Xu, G.Y., Yu, H.A., Hong, J. et al. J Mol Biol (1997) 268:468-481. DOI 10.1006/jmbi.1997.0933 · PubMed

Other PDB entries of the same protein (UniProt P05231 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1ALU 1.9 Å, Human interleukin-6
7NXZ 2.0 Å, Synthetic glycoform of Human Interleukin 6
4CNI 2.2 Å, Crystal structure of the Fab portion of Olokizumab in complex with IL- 6
4J4L 2.3 Å, Modular evolution and design of the protein binding interface
4NI7 2.4 Å, Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer…
4O9H 2.42 Å, Structure of Interleukin-6 in complex with a Camelid Fab fragment
8YWQ 2.51 Å, Crystal structure of the Fab fragment of the anti-IL-6 antibody I9H in complex with a…
4NI9 2.55 Å, Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer…
5FUC 2.7 Å, Biophysical and cellular characterisation of a junctional epitope antibody that locks…
4ZS7 2.93 Å, Structural mimicry of receptor interaction by antagonistic IL-6 antibodies
8YWR 2.93 Å, Crystal structure of the Fab fragment of the anti-IL-6 antibody 68F2 in complex with a…
8QY5 3.1 Å, Structure of interleukin 6.

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