2IOL: C-terminal MA3 domain of Pdcd4 (mouse); form 1

Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form 1. Determined by X-ray diffraction at 2.0 Å resolution. Released 14 Nov 2006.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Mus musculus
Chains: 2
Atoms: 2,110
Mol. weight: 35.01 kDa
Released: 14 Nov 2006

Explore 2IOL in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2IOL contains 17 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	326-341	16
α-helix	344-354	11
α-helix	357-359	3
α-helix	360-373	14
α-helix	378-392	15
α-helix	398-418	21
α-helix	422-435	14
α-helix	441-446	6

Chain B: 9 helices, 0 β-strands

Element	Residues	Length
α-helix	323-325	3
α-helix	326-341	16
α-helix	344-354	11
α-helix	357-359	3
α-helix	360-373	14
α-helix	378-392	15
α-helix	398-418	21
α-helix	422-435	14
α-helix	441-445	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Programmed Cell Death 4, Pdcd4	A, B	protein	150	Mus musculus	Q61823 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>2IOL_1 Programmed Cell Death 4, Pdcd4 (chains A, B)
GQQPVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIVMVLESTGESA
FKMILDLLKSLWKSSTITIDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGII
SKQLRDLCPSRGRKRFVSEGDGGRLKPESY

Primary citation

Structural basis for inhibition of translation by the tumor suppressor pdcd4. Laronde-Leblanc, N., Santhanam, A.N., Baker, A.R. et al. Mol Cell Biol (2007) 27:147-156. DOI 10.1128/MCB.00867-06 · PubMed

Other PDB entries of the same protein (UniProt Q61823 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2NSZ 1.15 Å, 1.15 Angstrom Crystal Structure of the MA3 domain of Pdcd4
2ION 1.57 Å, Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form2
2IOS 1.76 Å, Crystal structure of the C-terminal MA3 domain of Pdcd4 (mouse); form 3
3EIQ 3.5 Å, Crystal structure of Pdcd4-eIF4A
2HM8 Solution Structure of the C-terminal MA-3 domain of Pdcd4
2KZT Structure of the Tandem MA-3 Region of Pdcd4

Browse structure collections

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