2IWG: Ig gamma-1 chain C

Complex between the pryspry domain of TRIM21 and IgG fc. Determined by X-ray diffraction at 2.35 Å resolution. Released 27 Mar 2007.

Method: X-ray diffraction
Resolution: 2.35 Å
Organism: HOMO SAPIENS
Chains: 4
Atoms: 6,590
Mol. weight: 91.18 kDa
Ligands: FUC
Released: 27 Mar 2007

Explore 2IWG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2IWG contains 25 α-helices and 74 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 20 β-strands

Element	Residues	Length	Sheet
β-strand	239-243	5	1
α-helix	244-246	3
α-helix	247-250	4
β-strand	258-267	10	1
β-strand	274-279	6	2
β-strand	283-284	2	2
β-strand	288-289	2	1
α-helix	290-292	3
β-strand	293-295	3	1
β-strand	299-307	9	1
α-helix	310-314	5
β-strand	319-324	6	2
β-strand	332-336	5	2
α-helix	338-340	3
β-strand	344	1	3
α-helix	345-346	2
β-strand	347-351	5	4
α-helix	352-354	3
α-helix	355-359	5
β-strand	362-372	11	4
β-strand	373	1	3
β-strand	378-383	6	5
β-strand	386-387	2	5
β-strand	391-393	3	4
α-helix	394-396	3
β-strand	397-398	2	4
β-strand	404-413	10	4
α-helix	414-419	6
β-strand	423-428	6	5
α-helix	433-435	3
β-strand	436-441	6	5

Chain B: 0 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	6
β-strand	8	1	7
β-strand	17-19	3	6
β-strand	25-28	4	6
β-strand	48-49	2	8
β-strand	50	1	7
β-strand	54	1	8
β-strand	58-64	7	6
β-strand	71-77	7	8
β-strand	94-100	7	8
β-strand	104-107	4	8
β-strand	113-115	3	8
β-strand	123-129	7	6
β-strand	134-139	6	6
β-strand	145-150	6	6
β-strand	159-164	6	8
β-strand	177-179	3	6

Chain D: 11 helices, 20 β-strands

Element	Residues	Length	Sheet
β-strand	239-243	5	9
α-helix	244-246	3
α-helix	247-250	4
β-strand	258-267	10	9
β-strand	274-279	6	10
β-strand	283-284	2	10
α-helix	287	1
β-strand	288-289	2	9
α-helix	290-292	3
β-strand	293-295	3	9
β-strand	299-307	9	9
α-helix	310-314	5
β-strand	319-324	6	10
β-strand	332-336	5	10
α-helix	338-340	3
β-strand	344	1	11
α-helix	345-346	2
β-strand	347-351	5	12
α-helix	355-359	5
β-strand	362-372	11	12
β-strand	373	1	11
β-strand	378-383	6	13
β-strand	386-388	3	13
β-strand	391-393	3	12
α-helix	394-396	3
β-strand	397-398	2	12
β-strand	404-413	10	12
α-helix	414-419	6
β-strand	423-428	6	13
α-helix	433-435	3
β-strand	436-441	6	13

Chain E: 3 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	14
β-strand	8	1	15
β-strand	17-19	3	14
β-strand	25-28	4	14
β-strand	48-49	2	16
β-strand	50	1	15
β-strand	54	1	16
β-strand	58-64	7	14
β-strand	71-77	7	16
β-strand	94-100	7	16
β-strand	104-107	4	16
α-helix	112	1
β-strand	113-114	2	16
β-strand	123-129	7	14
β-strand	134-139	6	14
β-strand	145-150	6	14
β-strand	159-164	6	16
α-helix	169-171	3
α-helix	175-176	2
β-strand	177-179	3	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ig gamma-1 chain C	A, D	protein	207	HOMO SAPIENS	P01857 (AlphaFold model)
52 kda ro protein	B, E	protein	181	HOMO SAPIENS	P19474 (AlphaFold model)

Sequence of entity 1 (A, D), FASTA

>2IWG_1 IG GAMMA-1 CHAIN C (chains A, D)
GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQY
NSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRD
ELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR
WQQGNVFSCSVMHEALHNHYTQKSLSL

Sequence of entity 2 (B, E), FASTA

>2IWG_2 52 KDA RO PROTEIN (chains B, E)
HMVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYW
EVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPP
CQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCP
L

Ligands and cofactors

ID	Name	Formula	Copies
FUC	alpha-L-fucopyranose	C6 H12 O5	2

Primary citation

Structural Basis for Pryspry-Mediated Tripartite Motif (Trim) Protein Function. James, L.C., Keeble, A.H., Khan, Z. et al. Proc Natl Acad Sci U S A (2007) 104:6200. DOI 10.1073/PNAS.0609174104 · PubMed

Other PDB entries of the same protein (UniProt P01857 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4LLD 1.19 Å, Structure of wild-type IgG1 antibody heavy chain constant domain 1 and light chain…
3TV3 1.29 Å, Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with…
4LLQ 1.42 Å, Structure of redesigned IgG1 first constant and lambda domains (CH1:Clambda constant…
5HSF 1.52 Å, 1.52 Angstrom Crystal Structure of Fc fragment of Human IgG1.
6YT7 1.55 Å, Glycosylated knob/dummy-hole fc fragment
4NWU 1.6 Å, Crystal structure of APE1551, an anti-human NGF Fab with a nine amino acid insertion in…
1L6X 1.65 Å, Fc fragment of rituximab bound to a minimized version of the B-domain from protein A…
3TWC 1.65 Å, Crystal structure of broad and potent HIV-1 neutralizing antibody PGT127 in complex with…
5JIH 1.66 Å, Crystal structure of HER2 binding IgG1-Fc (Fcab STAB19)
3MCL 1.7 Å, Anti-beta-amyloid antibody c706 fab in space group P21
5U66 1.7 Å, Modified single helix from the B-domain of protein A bound to IgG1 Fc
6N35 1.75 Å, Anti-HIV-1 Fab 2G12 + Man1-2 re-refinement

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