2IXM: Human PTPA

Structure of human PTPA. Determined by X-ray diffraction at 1.5 Å resolution. Released 11 Jul 2006.

Method: X-ray diffraction
Resolution: 1.5 Å
Organism: HOMO SAPIENS
Chains: 1
Atoms: 2,681
Mol. weight: 34.8 kDa
Released: 11 Jul 2006

Explore 2IXM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2IXM contains 25 α-helices and 7 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 25 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	27-28	2	1
α-helix	34-40	7
β-strand	42	1	2
α-helix	43-58	16
α-helix	72-89	18
α-helix	92-95	4
α-helix	104-121	18
α-helix	126-131	6
α-helix	132-140	9
β-strand	145	1	3
β-strand	150-151	2	3
α-helix	153-168	16
α-helix	174-176	3
α-helix	177-179	3
α-helix	180-185	6
α-helix	186-198	13
α-helix	201	1
β-strand	202-203	2	3
α-helix	208-210	3
α-helix	218-226	9
α-helix	235-239	5
α-helix	241-247	7
α-helix	248-250	3
α-helix	252-263	12
α-helix	268-271	4
α-helix	273-278	6
α-helix	284-295	12
α-helix	296-300	5
α-helix	303-306	4
β-strand	310-311	2	1
β-strand	319	1	2
α-helix	320-321	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Serine/threonine-protein phosphatase 2A regulatory subunit B'	A	protein	303	HOMO SAPIENS	Q15257 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2IXM_1 SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B' (chains A)
TQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVSEAIEKLLA
LLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLVATVVPTHLAAAVPEVAVYL
KESVGNSTRIDYGTGHEAAFAAFLCCLCKIGVLRVDDQIAIVFKVFNRYLEVMRKLQKTY
RMEPAGSQGVWGLDDFQFLPFIWGSSQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILF
ITEMKTGPFAEHSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHP
VTS

Primary citation

Crystal Structure of the Pp2A Phosphatase Activator: Implications for its Pp2A-Specific Ppiase Activity. Leulliot, N., Vicentini, G., Jordens, J. et al. Mol Cell (2006) 23:413. DOI 10.1016/J.MOLCEL.2006.07.008 · PubMed

Other PDB entries of the same protein (UniProt Q15257 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2G62 1.6 Å, Crystal structure of human PTPA
4NY3 1.8 Å, Human PTPA in complex with peptide
2HV6 1.9 Å, Crystal structure of the phosphotyrosyl phosphatase activator
2HV7 2.5 Å, Crystal structure of phosphotyrosyl phosphatase activator bound to ATPgammaS
4LAC 2.82 Å, Crystal Structure of Protein Phosphatase 2A (PP2A) and PP2A phosphatase activator (PTPA)…

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