2J4O: TAB1

Structure of TAB1. Determined by X-ray diffraction at 2.25 Å resolution. Released 4 Sept 2006.

Method: X-ray diffraction
Resolution: 2.25 Å
Organism: HOMO SAPIENS
Chains: 1
Atoms: 2,819
Mol. weight: 43.73 kDa
Released: 4 Sept 2006

Explore 2J4O in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2J4O contains 13 α-helices and 19 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	23	1	1
β-strand	27-32	6	2
β-strand	35-37	3	3
β-strand	44-45	2	3
β-strand	51-58	8	1
β-strand	62-71	10	1
α-helix	75-86	12
α-helix	99-133	35
α-helix	146-148	3
α-helix	149-162	14
β-strand	165-174	10	1
β-strand	177-183	7	1
β-strand	187-193	7	2
β-strand	198-202	5	2
α-helix	212-219	8
α-helix	225-231	7
β-strand	234	1	4
β-strand	237	1	4
β-strand	241	1	5
β-strand	243-244	2	1
α-helix	246-250	5
α-helix	252-254	3
β-strand	267	1	5
α-helix	269-270	2
β-strand	271-277	7	1
β-strand	283-288	6	2
α-helix	290-300	11
α-helix	305-319	15
α-helix	323-343	21
α-helix	348-351	4
β-strand	354-355	2	3
β-strand	358-366	9	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1	A	protein	401	HOMO SAPIENS	Q15750 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2J4O_1 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 1 (chains A)
MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPEDSWLKFRSEN
NCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVERSFLES
IDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYV
ANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQEST
RRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAH
GPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRVKRIHSDTFASGGERARFCPRHEDMTL
LVRNFGYPLGEMSQPTPSPAPAAGGRVYPVSVPYSSAQSTS

Primary citation

Tak1-Binding Protein 1 is a Pseudophosphatase. Conner, S.H., Kular, G., Peggie, M. et al. Biochem J (2006) 399:427. DOI 10.1042/BJ20061077 · PubMed

Other PDB entries of the same protein (UniProt Q15750 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7NTH 1.97 Å, Structure of TAK1 in complex with compound 54
7NTI 1.98 Å, Structure of TAK1 in complex with compound 22
5JGA 2.0 Å, Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 11c
5V5N 2.01 Å, Crystal structure of Takinib bound to TAK1
8GW3 2.05 Å, Crystal structure of human TAK1 kinase domain fused with TAB1
5DIY 2.06 Å, Thermobaculum terrenum O-GlcNAc hydrolase mutant - D120N
5E7R 2.11 Å, Crystal structure of TL10-81 bound to TAK1-TAB1
4GS6 2.2 Å, Irreversible Inhibition of TAK1 Kinase by 5Z-7-Oxozeaenol
2POM 2.27 Å, TAB1 with manganese ion
5JH6 2.37 Å, Crystal structure of TL10-92 bound to TAK1-TAB1
5J7S 2.37 Å, Crystal structure of SM1-71 bound to TAK1-TAB1
5JK3 2.37 Å, Crystal structure of TL11-128 bound to TAK1-TAB1

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