2J7X: Estradiol-bound estrogen receptor beta lbd

Structure of estradiol-bound estrogen receptor beta lbd in complex with lxxll motif from NCOA5. Determined by X-ray diffraction at 2.1 Å resolution. Released 7 Nov 2006.

Method: X-ray diffraction
Resolution: 2.1 Å
Organisms: RATTUS NORVEGICUS, HOMO SAPIENS
Chains: 2
Atoms: 2,014
Mol. weight: 31.3 kDa
Ligands: EST, BCT
Released: 7 Nov 2006

Explore 2J7X in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2J7X contains 12 α-helices and 2 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	220-229	10
α-helix	231-234	4
α-helix	246-269	24
α-helix	274-276	3
α-helix	279-302	24
β-strand	308-312	5	1
β-strand	315-318	4	1
α-helix	319-324	6
α-helix	328-345	18
α-helix	349-360	12
α-helix	376-398	23
α-helix	403-436	34
α-helix	444-451	8

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	345-350	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Estrogen receptor beta	A	protein	255	RATTUS NORVEGICUS	Q62986 (AlphaFold model)
Nuclear receptor coactivator 5	B	protein	17	HOMO SAPIENS	Q9HCD5 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2J7X_1 ESTROGEN RECEPTOR BETA (chains A)
VKELLLSTLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAK
KIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGIL
EIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLASANQEAESSRKLTHLLNAVT
DALVWVIAKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEM
LNAHTLRGYKSSISG

Sequence of entity 2 (B), FASTA

>2J7X_2 NUCLEAR RECEPTOR COACTIVATOR 5 (chains B)
HPPAIQSLINLLADNRY

Ligands and cofactors

ID	Name	Formula	Copies
EST	Estradiol	C18 H24 O2	1
BCT	Bicarbonate ion	C H O3	1

Water and common crystallization additives (EDO, SO4) are not listed.

Primary citation

Structure of Agonist-Bound Estrogen Receptor Beta Lbd in Complex with Lxxll Motif from Ncoa5. Pike, A.C.W., Brzozowski, A.M., Hubbard, R.E. et al. To be published.

Other PDB entries of the same protein (UniProt Q62986 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2J7Y 1.8 Å, Structure of 17-epiestriol-bound estrogen receptor beta lbd in complex with lxxll motif…
1QKN 2.25 Å, Rat oestrogen receptor beta ligand-binding domain in complex with antagonist raloxifene
1HJ1 2.3 Å, Rat oestrogen receptor beta ligand-binding domain in complex with pure antioestrogen…

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