2JUR: Alpha-conotoxin RgIA

alpha RgIA, a Novel Conotoxin that Blocks the alpha9-alpha10 nAChR. Determined by solution NMR. Released 25 May 2011.

Method: Solution NMR
Chains: 1
Atoms: 106
Mol. weight: 1.59 kDa
Released: 25 May 2011

Explore 2JUR in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2JUR contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	6-8	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Alpha-conotoxin RgIA	A	protein	13		P0C1D0 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2JUR_1 Alpha-conotoxin RgIA (chains A)
GCCSEPRCRYRCR

Primary citation

Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues. Ellison, M., Feng, Z.P., Park, A.J. et al. J Mol Biol (2008) 377:1216-1227. DOI 10.1016/j.jmb.2008.01.082 · PubMed

Other PDB entries of the same protein (UniProt P0C1D0 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6HY7 2.26 Å, Crystal structure of alpha9 nAChR extracellular domain in complex with alpha-conotoxin…
7EGR 2.5 Å, Co-crystal structure of Ac-AChBPP in complex with RgIA
2JUQ alpha-RgIA, a Novel Conotoxin that Blocks the alpha9-alpha10 nAChR
2JUS alpha RgIA, a Novel Conotoxin that Blocks the alpha9-alpha10 nAChR
2JUT alpha RgIA, a Novel Conotoxin that Blocks the alpha9-alpha10 nAChR
2MTO Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA
2MTT Non-reducible analogues of alpha-conotoxin RgIA: [3,12]-cis dicarba RgIA
8W16 Pyroglutamaic acid position 1 synthetic analogue of RgIA
8W17 Lactam bridge synthetic analogue of RgIA

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