Structure of CD3epsilon-Nck2 first SH3 domain complex. Determined by solution NMR. Released 23 Sept 2008.
Explore 2JXB in 3D Show helices and sheets RCSB PDB PDBe
2JXB contains 1 α-helix and 6 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 32-36 | 5 | 1 |
| β-strand | 47 | 1 | 1 |
| β-strand | 54-60 | 7 | 1 |
| β-strand | 65-69 | 5 | 1 |
| β-strand | 75-79 | 5 | 1 |
| α-helix | 80-82 | 3 | |
| β-strand | 83 | 1 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| T-cell surface glycoprotein CD3 epsilon chain, Cytoplasmic protein NCK2 | A | protein | 86 | Homo sapiens | O43639 (AlphaFold model) |
>2JXB_1 T-cell surface glycoprotein CD3 epsilon chain, Cytoplasmic protein NCK2 (chains A) HMKERPPPVPNPDYNSLKKGSLVKNLHMTEEVIVIAKWDYTAQQDQELDIKKNERLWLLD DSKTWWRVRNAANRTGYVPSNYVERK
Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity. Takeuchi, K., Yang, H., Ng, E. et al. J Mol Biol (2008) 380:704-716. DOI 10.1016/j.jmb.2008.05.037 · PubMed
Other PDB entries of the same protein (UniProt O43639 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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