2K6D: CIN85 Sh3-C domain

CIN85 Sh3-C domain in complex with ubiquitin. Determined by solution NMR. Released 19 Aug 2008.

Method: Solution NMR
Organism: Homo sapiens
Chains: 2
Atoms: 1,108
Mol. weight: 15.77 kDa
Released: 19 Aug 2008

Explore 2K6D in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2K6D contains 6 α-helices and 12 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	271-273	3	1
β-strand	285	1	1
α-helix	286-287	2
β-strand	293-298	6	1
β-strand	304	1	1
β-strand	306-311	6	1
β-strand	314-319	6	1
α-helix	320-322	3
β-strand	324-325	2	1

Chain B: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	2
β-strand	14-16	3	2
α-helix	23-34	12
α-helix	38-40	3
β-strand	44-45	2	2
β-strand	48-49	2	2
α-helix	50-51	2
α-helix	57-59	3
β-strand	66-68	3	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
SH3 domain-containing kinase-binding protein 1	A	protein	62	Homo sapiens	Q96B97 (AlphaFold model)
Ubiquitin	B	protein	76	Homo sapiens	P0CG48 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2K6D_1 SH3 domain-containing kinase-binding protein 1 (chains A)
KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLL
PP

Sequence of entity 2 (B), FASTA

>2K6D_2 Ubiquitin (chains B)
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGC

Primary citation

Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination. Bezsonova, I., Bruce, M.C., Wiesner, S. et al. Biochemistry (2008) 47:8937-8949. DOI 10.1021/bi800439t · PubMed

Other PDB entries of the same protein (UniProt Q96B97 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5ABS 1.74 Å, Crystal structure of the C-terminal coiled-coil domain of CIN85 in space group P321
2BZ8 2.0 Å, N-terminal Sh3 domain of CIN85 bound to Cbl-b peptide
2YDL 2.05 Å, Crystal structure of SH3C from CIN85
2K9G Solution structure of the third SH3 domain of the Cin85 adapter protein
2N64 NMR Structure of the C-terminal Coiled-Coil Domain of CIN85
2O2O Solution structure of domain B from human CIN85 PROTEIN

Browse structure collections

About this viewer

MolViewer shows 2K6D directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.