2L58: Activator of apoptosis harakiri

Name: PDB 2L58: Solution structure of the cytosolic fragment 22-53 of Bcl-2 member Harakiri
Published: 2011-09-14
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: apoptosis

Solution structure of the cytosolic fragment 22-53 of Bcl-2 member Harakiri. Determined by solution NMR. Released 14 Sept 2011.

Method: Solution NMR
Organism: synthetic construct
Chains: 1
Atoms: 261
Mol. weight: 3.73 kDa
Released: 14 Sept 2011

Explore 2L58 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2L58 contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	7-30	24

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Activator of apoptosis harakiri	A	protein	33	synthetic construct	O00198 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2L58_1 Activator of apoptosis harakiri (chains A)
RLGLRSSAAQLTAARLKALGDELHQRTMWRRRX

Primary citation

Intrinsic order and disorder in the bcl-2 member harakiri: insights into its proapoptotic activity. Barrera-Vilarmau, S., Obregon, P., de Alba, E. PLoS One (2011) 6:e21413-e21413. DOI 10.1371/journal.pone.0021413 · PubMed

Other PDB entries of the same protein (UniProt O00198 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9UGP 1.39 Å, Crystal structure of MCL-1 in complex with HRK BH3
7P0U 1.99 Å, ORF virus encoded Bcl-2 homolog ORFV125 in complex with Puma BH3 peptide
6XY4 2.05 Å, Structural insight into sheep-pox virus mediated inhibition of apoptosis
9LI8 2.32 Å, Crystal structure of Bcl-xL in complex with HRK BH3 peptide
9LGU 2.97 Å, Crystal structure of Bcl-xL in complex with stapled HRK peptide
2L5B Solution structure of the transmembrane domain of Bcl-2 member Harakiri in micelles

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